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首页> 外文期刊>Cancer Cell >Targeting Immunosupportive Cancer Therapies: Accentuate the Positive, Eliminate the Negative
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Targeting Immunosupportive Cancer Therapies: Accentuate the Positive, Eliminate the Negative

机译：靶向免疫支持性癌症疗法：增强阳性，消除阴性

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In this Commentary we aim to provide an overview of some specific examples of cancer therapeutics, including targeted approaches using monoclonal antibodies and kinase inhibitors, as well as highlight novel approaches for enhancing immunological responses against tumors. We point out that a fundamental property of the cancer cell, genomic instability, confounds the targeted therapies that aim to induce cell death directly while simultaneously enhancing the potential for immunological attack by creating a large number of neoantigens. We argue for combinatorial strategies with agents that target tumor cells to release these antigens together with innovative therapies that enhance immunological responses by interfering with inhibitory checkpoints. 192
机译：在这篇评论中，我们旨在概述癌症治疗方法的一些特定实例，包括使用单克隆抗体和激酶抑制剂的靶向方法，并重点介绍增强针对肿瘤的免疫反应的新颖方法。我们指出癌细胞的基本特性，即基因组不稳定性，混淆了旨在直接诱导细胞死亡，同时通过产生大量新抗原而增强免疫攻击潜能的靶向疗法。我们主张与靶向肿瘤细胞以释放这些抗原的药物相结合的策略，以及通过干扰抑制性检查点来增强免疫应答的创新疗法。 192

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