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首页> 外文期刊>Cancer causes and control: CCC >Family history of various cancers and pancreatic cancer mortality in a large cohort.
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Family history of various cancers and pancreatic cancer mortality in a large cohort.

机译：大队列研究中各种癌症的家族史和胰腺癌死亡率。

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A family history of pancreatic cancer is associated with increased risk of pancreatic cancer, but uncertainty remains about the magnitude of this association, whether it varies by age or smoking and whether a family history of other cancers may also be associated with increased risk. We examined family history of 14 cancers and pancreatic cancer mortality among ~1.1 million men and women in Cancer Prevention Study-II (CPS-II). CPS-II participants completed a questionnaire at enrollment in 1982. During follow-up through 2006, there were 7,306 pancreatic cancer deaths. A family history of pancreatic cancer in a parent or sibling was associated with pancreatic cancer mortality [multivariable adjusted rate ratio (RR) = 1.66, 95% confidence interval (CI) 1.43-1.94]. This association was stronger among participants aged under 60 (RR = 2.89, 95% CI 1.67-5.02) than among participants aged 60 or older (RR = 1.61, 95% CI 1.37-1.88). Weaker associations were observed for family history of stomach cancer (RR = 1.23, 95% CI 1.11-1.37), liver cancer (RR = 1.25, 95% CI 1.10-1.43), and colorectal cancer (RR = 1.12, 95% CI 1.01-1.23). Results from this large prospective study indicate family history of pancreatic cancer is associated with a moderate increase in risk of pancreatic cancer, and also identify associations with the family history of certain other cancers which may be useful in generating hypotheses about shared risk factors.
机译：胰腺癌家族史与胰腺癌的风险增加相关，但是这种关联的程度仍然不确定，无论它是否因年龄或吸烟而异，以及其他癌症的家族史是否也可能与风险增加有关。在癌症预防研究II（CPS-II）中，我们检查了约110万名男性和女性中14种癌症的家族病史和胰腺癌死亡率。 CPS-II参与者于1982年在登记时完成了一份调查表。在整个2006年的随访中，有7,306例胰腺癌死亡。父母或兄弟姐妹的胰腺癌家族史与胰腺癌死亡率相关[多变量调整比率（RR）= 1.66，95％置信区间（CI）1.43-1.94]。 60岁以下的参与者（RR = 2.89，95％CI 1.67-5.02）比60岁或以上的参与者（RR = 1.61，95％CI 1.37-1.88）更强。观察到胃癌家族史（RR = 1.23，95％CI 1.11-1.37），肝癌（RR = 1.25，95％CI 1.10-1.43）和结直肠癌（RR = 1.12，95％CI 1.01）的家族史较弱。 -1.23）。这项大型前瞻性研究的结果表明，胰腺癌的家族史与胰腺癌风险的适度增加相关，并且还与某些其他癌症的家族史相关联，这可能有助于产生关于共同危险因素的假设。

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