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首页> 外文期刊>Cancer causes and control: CCC >Reproductive factors and hormone use and risk of adult gliomas.
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Reproductive factors and hormone use and risk of adult gliomas.

机译：生殖因子和激素的使用以及成年神经胶质瘤的风险。

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Previous research suggests there may be a hormonal influence on glioma risk as evidenced by lower rates in females, change in incidence rates around ages at menarche and menopause, and presence of hormone receptors in glial tumors. Using the large San Francisco Bay Area Adult Glioma Study, we investigated whether reported reproductive factors and hormone use were associated with gliomas overall or with histologic subtypes among female cases (n = 619) and controls (n = 650). We found that reproductive factors were generally not associated with gliomas. Weak to moderately elevated odds ratios were observed for self-reported later age at menarche (14+ vs. 12-13 years old: adjusted odds ratio (AOR) = 1.39, 95% confidence interval (CI): 1.02-1.89), particularly for non-glioblastoma histologies (AOR = 1.64, 95% CI: 1.11-2.43). Inverse associations were observed for ever self-reported use of exogenous hormones (oral contraceptive use: AOR = 0.72, 95% CI: 0.53-0.99; postmenopausal hormone use: AOR = 0.56, CI: 0.37-0.84). However, cumulative hormone exposure defined multiple ways demonstrated no clear pattern of association. The results of this study suggest that any protective effect of hormones on gliomas may be limited to exogenous hormones, but a more detailed history of exogenous hormone use is needed to confirm findings.
机译：先前的研究表明，对胶质瘤风险的影响可能是荷尔蒙，如女性发病率较低，初潮和更年期的发病率随年龄的变化以及神经胶质瘤中激素受体的存在所证明。使用大型的旧金山湾区成人神经胶质瘤研究，我们调查了报告的生殖因子和激素使用是否与胶质瘤总体相关或与女性病例（n = 619）和对照（n = 650）之间的组织学亚型相关。我们发现生殖因子通常与神经胶质瘤无关。在月经初潮时自我报告的较晚年龄观察到弱到中等升高的比值比（14岁对12-13岁：调整比值比（AOR）= 1.39，95％置信区间（CI）：1.02-1.89），特别是非胶质母细胞瘤的组织学检查（AOR = 1.64，95％CI：1.11-2.43）。自我报告使用外源激素的情况存在反向关联（口服避孕药使用：AOR = 0.72，95％CI：0.53-0.99;绝经后激素使用：AOR = 0.56，CI：0.37-0.84）。但是，累积激素暴露定义了多种方式，没有明确的关联模式。这项研究的结果表明，激素对神经胶质瘤的任何保护作用都可能仅限于外源激素，但需要更详细的外源激素使用史来证实其发现。

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