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首页> 外文期刊>Cancer causes and control: CCC >Effects of life event stress and social support on the odds of a >or= 2 cm breast cancer.
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Effects of life event stress and social support on the odds of a >or= 2 cm breast cancer.

机译：生活事件压力和社会支持对> 2 cm乳腺癌几率的影响。

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OBJECTIVE: To examine the contribution of life event and social support factors to diagnosis with a >or= 2 cm breast cancer. METHODS: We studied 1,459 Australian women aged 40-69 diagnosed in 2002-2003 with a first primary invasive breast cancer 1.1 cm or larger. We measured stressful life events, perceived stress levels, and social support in the year before diagnosis and collected information on other potential risk factors and confounders. RESULTS: The odds of a >or= 2 cm breast cancer relative to a 1.1-1.9 cm breast cancer were reduced in women who reported tension or change in an intimate relationship in the year before diagnosis (OR=0.71 95% CI 0.54-0.92; p=0.009); the reduction was greatest in women living with a partner (OR=0.64 95% CI 0.47-0.88; p=0.006) and was largely unaffected by adjustment for other variables independently associated with a >or= 2 cm breast cancer in our study. There was no evidence that the total number or severity of all studied life events influenced cancer size. Low partner support increased the odds of a >or= 2 cm cancer but only in women not living with a partner. CONCLUSION: Intimate relationship stress may reduce risk of a >or= 2 cm breast cancer. Suppression by stress of estrogen synthesis and metabolism is a possible mechanism.
机译：目的：探讨生活事件和社会支持因素对≥2 cm乳腺癌诊断的贡献。方法：我们研究了2002年至2003年诊断为首发原发性浸润性乳腺癌1.1厘米或更大的1459名40-69岁的澳大利亚妇女。我们在诊断前一年测量了压力性生活事件，感觉到的压力水平和社会支持，并收集了有关其他潜在风险因素和混杂因素的信息。结果：在诊断前一年中报告紧张或有亲密关系改变的女性，患≥2cm乳腺癌相对于1.1-1.9 cm乳腺癌的几率降低了（OR = 0.71 95％CI 0.54-0.92 ; p = 0.009）;与伴侣生活在一起的女性的减少幅度最大（OR = 0.64 95％CI 0.47-0.88; p = 0.006），并且在我们的研究中，很大程度上不受其他独立于≥2cm乳腺癌相关变量的调整的影响。没有证据表明所有研究过的生活事件的总数或严重程度都会影响癌症的大小。伴侣的支持率低会增加罹患大于或等于2厘米癌症的几率，但仅限于没有伴侣生活的女性。结论：亲密关系压力可以减少患≥2 cm乳腺癌的风险。应激抑制雌激素合成和代谢是一种可能的机制。

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