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首页> 外文期刊>Cancer causes and control: CCC >C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.
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C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.

机译：65岁及以上男性的C反应蛋白，白介素6和前列腺癌风险。

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Inflammation is believed to play a role in prostate cancer (PCa) etiology, but it is unclear whether inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6) associate with PCa risk in older men. Using Cox regression, we assessed the relationship between baseline concentrations of CRP and IL-6 and the subsequent PCa risk in the Cardiovascular Health Study, a population-based cohort study of mostly European American men of ages >64 years (n = 2,234; mean follow-up = 8.7 years; 215 incident PCa cases). We also tested associations between CRP and IL-6 tagSNPs and PCa risk, focusing on SNPs that are known to associate with circulating CRP and/or IL-6. Neither CRP nor IL-6 blood concentrations was associated with PCa risk. The C allele of IL-6 SNP rs1800795 (-174), a known functional variant, was associated with increased risk in a dominant model (HR = 1.44; 95% CI = 1.03-2.01; p = 0.03), but was not statistically significant after accounting for multiple tests (permutation p = 0.21). Our results suggest that circulating CRP and IL-6 do not influence PCa risk. SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation.
机译：人们认为炎症在前列腺癌（PCa）的病因中起作用，但目前尚不清楚炎症标志物C反应蛋白（CRP）和白介素6（IL-6）是否与老年男性的PCa风险相关。使用Cox回归，我们在心血管健康研究中评估了CRP和IL-6的基线浓度与随后的PCa风险之间的关系，该研究是一项基于人群的队列研究，主要针对年龄> 64岁的欧洲裔美国人（n = 2,234;平均随访= 8.7年; 215例PCa病例）。我们还测试了CRP和IL-6 tagSNP与PCa风险之间的关联，重点研究了已知与循环CRP和/或IL-6相关的SNP。 CRP和IL-6血药浓度均与PCa风险无关。 IL-6 SNP rs1800795（-174）的C等位基因是已知的功能变异，与显性模型中的风险增加相关（HR = 1.44; 95％CI = 1.03-2.01; p = 0.03），但无统计学意义在考虑了多次测试后的显着性（排列p = 0.21）。我们的结果表明，循环中的CRP和IL-6不会影响PCa风险。在该队列中，CRP位点的SNP与PCa风险无关，而rs1800795与PCa风险之间的关联值得进一步研究。

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