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首页> 外文期刊>Cancer causes and control: CCC >Pooled analysis of the association of PTGS2 rs5275 polymorphism and NSAID use with invasive ovarian carcinoma risk.
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Pooled analysis of the association of PTGS2 rs5275 polymorphism and NSAID use with invasive ovarian carcinoma risk.

机译：PTGS2 rs5275基因多态性和NSAID使用与浸润性卵巢癌风险的关联分析。

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摘要

Inflammation is postulated to play an important role in ovarian carcinogenesis. Prostaglandin endoperoxide synthase 2 (PTGS2) is responsible for the conversion of arachidonic acid to prostaglandins in response to inflammation. In a pooled analysis of two population-based studies, the Hawaii Ovarian Cancer Case-Control Study and the New England Case-Control Study, including 1,025 women with invasive ovarian carcinoma and 1,687 cancer-free controls, the association of ovarian cancer risk with the PTGS2 rs5275 polymorphism and the use of nonsteroidal antiinflammatory drugs (NSAIDs) were examined. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. In the pooled analysis, the CC genotype was associated with a reduced risk of nonserous ovarian carcinoma (OR = 0.66; CI: 0.44-0.98). In addition, the lowest risk was observed among carriers of the CC genotype who were users of only nonaspirin NSAIDs (OR = 0.43; CI:0.20-0.93) in all women combined. The association of PTGS2 rs5275 with nonserous ovarian carcinoma and possible effect modification by NSAID use needs further validation, preferably in prospective studies.
机译：假定炎症在卵巢癌发生中起重要作用。前列腺素内过氧化物合酶2（PTGS2）负责响应炎症反应将花生四烯酸转化为前列腺素。在两项基于人群的研究（夏威夷卵巢癌病例对照研究和新英格兰病例对照研究）的汇总分析中，包括1,025名患有浸润性卵巢癌的妇女和1,687名无癌的对照，卵巢癌风险与肝癌的相关性审查了PTGS2 rs5275多态性和非甾体抗炎药（NSAIDs）的使用。使用无条件逻辑回归估计赔率（OR）和95％置信区间（CI）。在汇总分析中，CC基因型与非浆液性卵巢癌风险降低相关（OR = 0.66; CI：0.44-0.98）。此外，在所有女性合并使用CC基因型的携带者中，仅使用非阿司匹林NSAID的风险最低（OR = 0.43; CI：0.20-0.93）。 PTGS2 rs5275与非浆液性卵巢癌的关联以及使用NSAID可能引起的效应改变需要进一步验证，尤其是在前瞻性研究中。

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