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首页> 外文期刊>British journal of biomedical science >Cervical lymph node thyroglobulin measurement in washout of fine-needle aspirates for diagnosis of papillary thyroid cancer metastases
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Cervical lymph node thyroglobulin measurement in washout of fine-needle aspirates for diagnosis of papillary thyroid cancer metastases

机译：颈淋巴结甲状腺球蛋白在细针抽吸液冲洗中的测定，以诊断甲状腺乳头状癌转移

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摘要

Background: Patients with papillary thyroid cancer (PTC) and enlarged cervical lymph nodes (CLNs) are usually assessed by fine-needle aspiration biopsy cytology (FNAB-C). Thyroglobulin (Tg) is frequently detected in washout of fine-needle aspirates (FNA) of these lymph nodes. The aim of this study was to evaluate the accuracy of the measurement of FNAB-Tg in the washout of FNAB in combination with FNAB-C to detect CLN metastases in PTC.Methods: We retrospectively evaluated 163 surgically proven CLNs. Ultrasound-guided FNAB-C and FNAB-Tg measurements were performed and the ultrasound features were evaluated.Results: The sensitivity, specificity and accuracy of FNAB-C, FNAB-Tg and FNAB-C/FNAB-Tg in diagnosis of metastatic CLNs were 85.7, 87.8 and 71.6%, were 80.5, 87 and 82.8% and were 97.1, 96.3 and 95.7%, respectively. The diagnostic sensitivity, specificity and accuracy of FNAB-C/FNAB-Tg for metastatic CLNs was significantly higher than that of FNAB-C or FNAB-Tg alone (p<0.01).Conclusion: Combined US-guided FNAB-C and FNAB-Tg can improve the accuracy for diagnosis of metastatic CLNs in patients with PTC.
机译：背景：甲状腺乳头状癌（PTC）和颈淋巴结肿大（CLN）的患者通常通过细针穿刺活检细胞学（FNAB-C）进行评估。甲状腺球蛋白（Tg）通常在这些淋巴结的细针抽吸物（FNA）冲刷中检测到。这项研究的目的是评估结合FNAB-C检测PTC中CLN转移的FNAB冲洗中FNAB-Tg测量的准确性。方法：我们回顾性评估了163种经手术证实的CLN。结果：通过分析FNAB-C，FNAB-Tg和FNAB-C / FNAB-Tg在转移性CLNs诊断中的敏感性，特异性和准确性。 85.7、87.8和71.6％分别为80.5、87和82.8％，分别为97.1、96.3和95.7％。 FNAB-C / FNAB-Tg对转移性CLNs的诊断敏感性，特异性和准确性显着高于单独的FNAB-C或FNAB-Tg（p <0.01）。结论：联合美国指导的FNAB-C和FNAB- Tg可提高PTC患者转移性CLN诊断的准确性。

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