Wiping DNA Methylation: Wip1 Regulates Genomic Fluidity on Cancer

Mu?oz-LopezM.; MedinaP.; Garcia-PerezJ.

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Wiping DNA Methylation: Wip1 Regulates Genomic Fluidity on Cancer

机译：清除DNA甲基化：Wip1调节癌症的基因组流动性。

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Wip1 phosphatase plays an important role in cancer by inactivating p53 and INK4a/ARF pathways. In this issue of Cancer Cell, Filipponi and colleagues further connect the oncogenic role of Wip1 with heterochromatin dynamics, transposable element expression, and a mutation-prone environment that may enhance heterogeneity and ultimately contribute to tumor evolution.

机译：Wip1磷酸酶通过灭活p53和INK4a / ARF途径在癌症中发挥重要作用。在本期《癌细胞》杂志中，Filipponi及其同事将Wip1的致癌作用与异染色质动力学，转座因子表达以及易于突变的环境（可能增强异质性并最终促进肿瘤进化）联系起来。

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《Cancer Cell》 |2013年第4期|共3页
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Mu?oz-LopezM.; MedinaP.; Garcia-PerezJ.;
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正文语种 eng
中图分类肿瘤学;
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1. Wiping DNA Methylation: Wip1 Regulates Genomic Fluidity on Cancer [J] . Mu?oz-LopezM., MedinaP., Garcia-PerezJ. Cancer Cell . 2013,第4期

机译：清除DNA甲基化：Wip1调节癌症的基因组流动性。
2. Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny [J] . W Lee, J Johnson, D J Gough, Cell death & disease. . 2015,第2期

机译：线粒体DNA拷贝数受干细胞和癌细胞及其分化后代中 POLGA 的DNA甲基化和去甲基化的调节
3. Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b. [J] . Gowher H, Stuhlmann H, Felsenfeld G Genes and Development: a Journal Devoted to the Molecular Analysis of Gene Expression in Eukaryotes, Prokaryotes, and Viruses . 2008,第15期

机译：Vezf1通过影响基因组DNA甲基转移酶Dnmt3b的表达来调节基因组DNA甲基化。
4. Targeted profiling of 5-(hydroxy)methylcytosine in genomic DNA from human livers: Next-generation sequencing of target enriched DNA reveals unexpectedly high interindividual variability of cytosine methylation and hydroxymethylation [C] . Ivanov Maxim, Ingelman-Sundberg Magnus, Kals Mart, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：人类肝脏基因组DNA中5-（羟）甲基胞嘧啶的靶向分析：富含靶DNA的下一代测序揭示了胞嘧啶甲基化和羟甲基化的意料之外的高度个体差异
5. Genomic and epigenomic characterization of global DNA hypomethylation in human epithelial ovarian cancer [D] . Zhang, Wa. 2014

机译：人类上皮性卵巢癌中整体DNA低甲基化的基因组和表观基因组学表征
6. Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b [O] . Humaira Gowher, Heidi Stuhlmann, Gary Felsenfeld 2008

机译：Vezf1通过影响基因组DNA甲基转移酶Dnmt3b的表达来调节基因组DNA甲基化
7. Wiping DNA Methylation: Wip1 Regulates Genomic Fluidity on Cancer [O] . Muñoz-Lopez Martin, Medina Pedro P., Garcia-Perez Jose L. 2013

机译：清除DNA甲基化：Wip1调节癌症的基因组流动性。
8. High Throughput Analysis of the Role of Genomic Methylation in Breast Cancer by Methylation-Sensitive Comparative Genomic Hybridization [R] . Ramaswamy, A. 2001

机译：通过甲基化敏感的比较基因组杂交分析乳腺癌中基因组甲基化作用的高通量分析

Wiping DNA Methylation: Wip1 Regulates Genomic Fluidity on Cancer

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