Targeting the tumor and its microenvironment by a dual-function decoy Met receptor.

Michieli P; Mazzone M; Basilico C; Cavassa S; Sottile A; Naldini L; Comoglio PM

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Targeting the tumor and its microenvironment by a dual-function decoy Met receptor.

机译：通过双重功能诱饵Met受体靶向肿瘤及其微环境。

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摘要

Met, the receptor for hepatocyte growth factor (HGF), is activated in human cancer by both ligand-dependent and -independent mechanisms. We engineered a soluble Met receptor (decoy Met) that interferes with both HGF binding to Met and Met homodimerization. By lentiviral vector technology, we achieved local or systemic delivery of decoy Met in mice. We provide evidence that in vivo expression of decoy Met (1) inhibits tumor cell proliferation and survival in a variety of human xenografts, (2) impairs tumor angiogenesis by preventing host vessel arborization, (3) suppresses or prevents the formation of spontaneous metastases, and (4) synergizes with radiotherapy in inducing tumor regression, without (5) affecting housekeeping physiological functions in the adult animal.

机译：Met是肝细胞生长因子（HGF）的受体，通过配体依赖性和非依赖性机制在人类癌症中被激活。我们设计了一种可溶的Met受体（诱饵Met），该受体可干扰HGF与Met的结合以及Met的同二聚作用。通过慢病毒载体技术，我们实现了在小鼠中局部或全身递送诱饵Met。我们提供的证据表明，诱饵Met的体内表达（1）在多种人类异种移植物中抑制肿瘤细胞的增殖和存活;（2）通过阻止宿主血管的乔化损害肿瘤血管生成;（3）抑制或阻止自发转移的形成，（4）与放疗协同作用以诱导肿瘤消退，而不会（5）影响成年动物的管家生理功能。

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来源
《Cancer Cell》 |2004年第1期|共13页
作者
Michieli P; Mazzone M; Basilico C; Cavassa S; Sottile A; Naldini L; Comoglio PM;
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正文语种 eng
中图分类肿瘤学;
关键词
Methionine; Neoplasms; receptor; Hepatocyte Growth Factor; physiological aspects; 甲硫氨酸; 肿瘤; 肝细胞生长因子;

机译：Methionine;Neoplasms;receptor;Hepatocyte Growth Factor;physiological aspects;甲硫氨酸;肿瘤;肝细胞生长因子;

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专利

1. Targeting the tumor and its microenvironment by a dual-function decoy Met receptor. [J] . Michieli P, Mazzone M, Basilico C, Cancer Cell . 2004,第1期

机译：通过双重功能诱饵Met受体靶向肿瘤及其微环境。
2. The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor. [J] . F Re, M Muzio, M De Rossi, The Journal of Experomental Medicine . 1994,第2期

机译：II型“受体”作为多形核白细胞中白介素1的诱饵靶：地塞米松的诱导特征和释放诱饵受体的配体结合特性。
3. MiR-142 modulates human pancreatic cancer proliferation and invasion by targeting hypoxia-inducible factor 1 (HIF-1???±) in the tumor microenvironments MiR-142 modulates human pancreatic cancer proliferation and invasion by targeting hypoxia-inducible factor 1 (HIF-1???±) in the tumor microenvironments MiR-142 modulates human pancreatic cancer proliferation and invasion by targeting hypoxia-inducible factor 1 (HIF-1???±) in the tumor microenvironments [J] . Xuejun Gong, Yebin Lu, Wei Wei, Biology Open . 2017,第2期

机译：MiR-142通过在肿瘤微环境中靶向缺氧诱导因子1（HIF-1 ???±）来调节人胰腺癌的增殖和侵袭MiR-142通过靶向低氧诱导因子1（HIF-在肿瘤微环境中的1 ???±）MiR-142通过在肿瘤微环境中靶向缺氧诱导因子1（HIF-1 ???±）来调节人胰腺癌的增殖和侵袭。
4. Novel antitumor mechanisms of curcumin: implication of altered tumor metabolism, reconstituted tumor microenvironment and augmented myelopoiesis [C] . Naveen Kumar Vishvakarma International Conference on Natural Products Utilization . 2014

机译：姜黄素的新型抗肿瘤机制：改变肿瘤代谢的含义，重构肿瘤微环境和增强髓鞘
5. Reducing Metastatic Potential by Targeting Tumor Metabolism and Understanding the Free-floating Tumor Microenvironments of Metastasis. [D] . Chakrabarti, Kristi R. 2016

机译：通过靶向肿瘤代谢并了解自由转移的肿瘤微环境转移来降低转移潜能。
6. Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: decoy trap and kill chemotherapy moves toward the clinic [O] . Kentaro Igarashi, Kei Kawaguchi, Tasuku Kiyuna, 2018

机译：靶向鼠伤寒沙门氏菌A1-R结合重组蛋氨酸酶和顺铂在源自患者的原位异种移植（PDOX）小鼠模型中消除了骨肉瘤顺铂耐药的肺转移：诱饵诱捕和杀死化学疗法走向临床
7. Targeting the tumor and its microenvironment by a dual-function decoy Met receptor [O] . Michieli Paolo, Mazzone Massimiliano, Basilico Cristina, 2004

机译：通过双功能诱饵Met受体靶向肿瘤及其微环境

Targeting the tumor and its microenvironment by a dual-function decoy Met receptor.

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