APRIL promotes B-1 cell-associated neoplasm.

Planelles L; Carvalho Pinto CE; Hardenberg G; Smaniotto S; Savino W; Gomez Caro R; Alvarez Mon M; de Jong J; Eldering E; Martinez A C; Medema JP; Hahne M

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APRIL promotes B-1 cell-associated neoplasm.

机译：APRIL促进B-1细胞相关肿瘤。

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A tumor-supporting role for the TNF-like ligand APRIL has been suggested. Here we describe that 9- to 12-month-old APRIL transgenic mice develop lymphoid tumors that originate from expansion of the peritoneal B-1 B cell population. Aging APRIL transgenic mice develop progressive hyperplasia in mesenteric lymph nodes and Peyer's patches, disorganization of affected lymphoid tissues, mucosal and capsular infiltration, and eventual tumor cell infiltration into nonlymphoid tissues such as kidney and liver. We detected significantly increased APRIL levels in sera of B cell chronic lymphoid leukemia (B-CLL) patients, indicating that APRIL promotes onset of B-1-associated neoplasms and that APRIL antagonism may provide a therapeutic strategy to treat B-CLL patients.

机译：已经提出了TNF样配体APRIL的肿瘤支持作用。在这里，我们描述了9到12个月大的APRIL转基因小鼠发生了淋巴样肿瘤，其起源于腹膜B-1 B细胞群体的扩大。衰老的APRIL转基因小鼠在肠系膜淋巴结和Peyer斑中发生进行性增生，受影响的淋巴组织紊乱，粘膜和荚膜浸润，最终肿瘤细胞浸润到非淋巴组织（如肾脏和肝脏）中。我们检测到B细胞慢性淋巴白血病（B-CLL）患者的血清中APRIL水平显着增加，表明APRIL促进了B-1相关肿瘤的发作，并且APRIL拮抗作用可能提供治疗B-CLL患者的治疗策略。

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来源
《Cancer Cell》 |2004年第4期|共10页
作者
Planelles L; Carvalho Pinto CE; Hardenberg G; Smaniotto S; Savino W; Gomez Caro R; Alvarez Mon M; de Jong J; Eldering E; Martinez A C; Medema JP; Hahne M;
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正文语种 eng
中图分类肿瘤学;
关键词
Neoplasms; Leukemia; Lymphocytic; Chronic; Cells; Laboratory mice; 肿瘤; 白血病; 淋巴细胞; 慢性; 细胞;

机译：Neoplasms;Leukemia;Lymphocytic;Chronic;Cells;Laboratory mice;肿瘤;白血病;淋巴细胞;慢性;细胞;

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1. APRIL promotes B-1 cell-associated neoplasm. [J] . Planelles L, Carvalho Pinto CE, Hardenberg G, Cancer Cell . 2004,第4期

机译：APRIL促进B-1细胞相关肿瘤。
2. C/EBP delta links IL-6 and HIF-1 signaling to promote breast cancer stem cell-associated phenotypes [J] . Balamurugan Kuppusamy, Mendoza-Villanueva Daniel, Sharan Shikha, Clinical and experimental metastasis . 2019,第2期

机译：C / EBP Delta链接IL-6和HIF-1信号，以促进乳腺癌干细胞相关表型
3. Myosin II Synergizes with F-Actin to Promote DNGR-1-Dependent Cross-Presentation of Dead Cell-Associated Antigens [J] . Oliver Schulz, Pavel Han?, Jan P. B?ttcher, Cell Reports . 2018,第2期

机译：肌球蛋白II与F-肌动蛋白协同作用，促进死细胞相关抗原的DNGR-1依赖性交叉表达。
4. Trojan Horse or Immunologic Catalyst? The Role of Cell-associated Virus in the Mucosal Transmission and Immunopathogenesis of FIV [C] . Mary Jo Burkhard Annual Meeting of the American Society for Veterinary Clinical Pathology . 2005

机译：特洛伊木马或免疫催化剂？细胞相关病毒在FIV的粘膜传播和免疫病理中的作用
5. Aflatoxin B-1 metabolism, CYP1A induction, and the influence of CYP1A induction on Aflatoxin B-1 metabolism in Zebrafish [D] . Troxel, Claudia McLaughlin. 1996

机译：黄曲霉毒素B-1代谢，CYP1A诱导和CYP1A诱导对斑马鱼黄曲霉毒素B-1代谢的影响
6. APRIL mediates peritoneal B-1 cell homeostasis [O] . Vishal J. Sindhava, Jean L. Scholz, William Stohl, -1

机译：APRIL介导腹膜B-1细胞稳态
7. APRIL promotes B-1 cell-associated neoplasm [O] . Planelles, Lourdes, Carvalho-Pinto, Carla E., Hardenberg, Gijs, 2004

机译：APRIL促进B-1细胞相关肿瘤

APRIL promotes B-1 cell-associated neoplasm.

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