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首页> 外文期刊>Cancer Cell >Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.
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Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.

机译：儿童急性淋巴细胞白血病中与化疗交叉耐药相关基因和治疗反应的鉴定。

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Acute lymphoblastic leukemia (ALL) can be cured with combination chemotherapy in over 75% of children, but the cause of treatment failure in the remaining patients is unknown. We determined the sensitivity of ALL cells to individual antileukemic agents in 441 patients and used a genome-wide approach to identify 45 genes differentially expressed in ALL exhibiting crossresistance to prednisolone, vincristine, asparaginase, and daunorubicin. We also identified a distinct phenotype of discordant resistance to asparaginase and vincristine and 139 genes whose expression was associated with this novel phenotype. The expression of these genes discriminated treatment outcome in two independent patient populations, identifying a subset of patients with a markedly inferior outcome (37% +/- 13% 5 year DFS).
机译：联合化疗可治愈超过75％的儿童急性淋巴细胞白血病（ALL），但其余患者治疗失败的原因尚不清楚。我们确定了441例患者中ALL细胞对单个抗白血病药物的敏感性，并采用全基因组方法鉴定了在ALL中差异表达的45个基因，这些药物对泼尼松龙，长春新碱，天冬酰胺酶和柔红霉素具有交叉耐药性。我们还确定了对天冬酰胺酶和长春新碱的抗药性不同的独特表型，以及与该新表型相关的139个基因。这些基因的表达区分了两个独立患者群体中的治疗结果，确定了亚组患者的预后显着差（5年DFS为37％+/- 13％）。

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