Integrated breast cancer genomics.

Edgren H; Kallioniemi O

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Integrated breast cancer genomics.

机译：综合乳腺癌基因组学。

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Predicting survival and therapy responses of breast cancer patients is a significant challenge. Two studies in this issue of Cancer Cell present a novel integrated analysis of genomic and transcriptomic profiles of 145 primary breast cancers and 51 established cell lines. Data from clinical tumors highlighted mechanisms of disease and facilitated identification of potential therapeutic targets and prognostic biomarkers. An extensive well-characterized cancer cell line resource opens up opportunities to explore the determinants of cellular responses to existing and emerging therapies. Taken together, these studies illustrate how integrated molecular profiling may one day significantly impact diagnosis and therapeutic choice in human breast cancer.

机译：预测乳腺癌患者的生存和治疗反应是一项重大挑战。本期《癌细胞》杂志上的两项研究提出了对145种原发性乳腺癌和51种已建立的细胞系的基因组和转录组谱进行新颖的综合分析。来自临床肿瘤的数据突出了疾病的机制，并促进了潜在治疗靶标和预后生物标志物的鉴定。广泛表征的癌细胞系资源为探索细胞对现有和新兴疗法反应的决定因素提供了机会。综上所述，这些研究表明，整合的分子谱分析可能一天如何显着影响人类乳腺癌的诊断和治疗选择。

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《Cancer Cell》 |2006年第6期|共2页
作者
Edgren H; Kallioniemi O;
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正文语种 eng
中图分类肿瘤学;
关键词
Breast Neoplasms; Genomics; 乳腺肿瘤;

机译：Breast Neoplasms;Genomics;乳腺肿瘤;

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专利

1. Integrated breast cancer genomics. [J] . Edgren H, Kallioniemi O Cancer Cell . 2006,第6期

机译：综合乳腺癌基因组学。
2. "Lineage addiction" in human cancer: lessons from integrated genomics. [J] . Garraway LA, Weir BA, Zhao X, Cold Spring Harbor symposia on quantitative biology. . 2005,第0期

机译：人类癌症中的“谱系成瘾”：来自整合基因组学的教训。
3. Unraveling the complexity of endocrine resistance in breast cancer by functional genomics. [J] . Swanton C, Downward J Cancer Cell . 2008,第2期

机译：通过功能基因组学揭示乳腺癌内分泌抗性的复杂性。
4. An Integrated Microfluidic System for Early Diagnosis of Breast Cancer in Liquid Biopsy by Using Microrna and FET Biosensors [C] . Chi-Chien Huang, Yu-Husan Kuo, Yi-Sin Chen, IEEE International Conference on Micro Electro Mechanical Systems . 2021

机译：用MicroRNA和FET生物传感器将液体活组织检查早期乳腺癌早期诊断综合微流体系统
5. Computer-Integrated Methods for Breast Cancer Surgery and Brachytherapy Guidance [D] . Vaughan, Thomas. 2019

机译：乳腺癌手术和近距离放射治疗指导的计算机综合方法
6. Identification of key differentially expressed genes between ER-positive/HER2-negative breast cancer and ER-negative/HER2-negative breast cancer using integrated bioinformatics analysis [O] . Siyuan Gan, Haixia Dai, Rujia Li, 2020

机译：使用综合生物信息分析鉴定ER阳性/ HER2阴性乳腺癌和ER阴性/ HER2阴性乳腺癌之间的关键差异表达基因
7. Biomarkers in Breast Cancer: An Integrated Analysis of Comprehensive Genomic Profiling and PD‐L1 Immunohistochemistry Biomarkers in 312 Patients with Breast Cancer [O] . Richard S.P. Huang, Xinyan Li, James Haberberger, 2020

机译：乳腺癌中的生物标志物：312例乳腺癌患者综合基因组分析和PD-L1免疫组织化学生物标志物的综合分析

Integrated breast cancer genomics.

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