Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

Becker Annette; Thakur Basant Kumar; Weiss Joshua Mitchell; Kim Han Sang; Peinado Hector; Lyden David

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Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

机译：癌症中的细胞外囊泡：转移的细胞间介体

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Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stomal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.

机译：肿瘤分泌的细胞外小泡（EVs）是局部和远距离微环境中肿瘤细胞与基质细胞之间细胞间通讯的关键介质。因此，电动汽车在原发性肿瘤生长和转移性进化中都起着至关重要的作用。电动汽车协调了多种系统病理生理过程，例如凝血，血管渗漏以及造口受体细胞的重新编程，以支持转移前的利基形成和随后的转移。在临床上，电动汽车可能是癌症进展的生物标志物和新的治疗靶标，特别是对于预测和预防未来的转移性发展。

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《Cancer Cell》 |2016年第6期|共13页
作者
Becker Annette; Thakur Basant Kumar; Weiss Joshua Mitchell; Kim Han Sang; Peinado Hector; Lyden David;
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正文语种 eng
中图分类肿瘤学;
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1. Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis [J] . Becker Annette, Thakur Basant Kumar, Weiss Joshua Mitchell, Cancer Cell . 2016,第6期

机译：癌症中的细胞外囊泡：转移的细胞间介体
2. Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation [J] . Kerry L. Inder, Jayde E. Ruelcke, Lara Petelin, Journal of Extracellular Vesicles . 2014,第1期

机译：Cavin-1 / PTRF改变前列腺癌细胞衍生的细胞外囊泡含量和内在化作用，以减弱细胞外囊泡介导的破骨细胞生成和成骨细胞增殖
3. Cell-to-cell communication via extracellular vesicles among human pancreatic cancer cells derived from the same patient [J] . Chiba Mitsuru, Kubota Shiori, Sakai Ayaka, Molecular medicine reports . 2018,第4期

机译：通过来自同一患者的人胰腺癌细胞中通过细胞内囊泡的细胞对细胞通信
4. Enrichment and Analysis of Breast Cancer Cell-Derived Extracellular Vesicles by Laser-Assisted Protein Adsorption in Thermoplastic Microchannels [C] . André Kling, Jonas Nikoloff, Mario A. Saucedo-Espinosa, International Conference on Solid-State Sensors, Actuators and Microsystems . 2021

机译：激光辅助蛋白质吸附在热塑性微通道中的富集和分析乳腺癌细胞源细胞外囊泡
5. Extracellular Vesicles as Mediators of the Adaptive Survival Response to Hypoxia in Pancreatic Cancer Cells [D] . Patton, Mary Catherine. 2020

机译：细胞外囊泡作为胰腺癌细胞缺氧的适应性生存反应的介质
6. Extracellular vesicles in cancer: cell-to-cell mediators of metastasis [O] . Annette Becker, Basant Kumar Thakur, Joshua Mitchell Weiss, -1

机译：癌症中的细胞外囊泡：转移的细胞间介体
7. Participation of Extracellular Vesicles from Zika-Virus-Infected Mosquito Cells in the Modification of Naïve Cells’ Behavior by Mediating Cell-to-Cell Transmission of Viral Elements [O] . Pedro Pablo Martínez-Rojas, Elizabeth Quiroz-García, Verónica Monroy-Martínez, 2020

机译：通过介导病毒元素的细胞对细胞传播Zika-Virus感染蚊细胞的细胞外囊的参与
8. Fibrin(ogen) -Mediated Extracellular Transport of Breast Cancer Cells by Macrophages: A New Idea Regarding Metastasis [R] . Retzinger, G. S. 2004

机译：纤维蛋白（ogen）介导巨噬细胞对乳腺癌细胞的细胞外转运：关于转移的新思路

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

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