A functional approach to questions about life, death, and phosphorylation.

Bernards R

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A functional approach to questions about life, death, and phosphorylation.

机译：一种有关生命，死亡和磷酸化问题的实用方法。

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The success of the family of kinases as targets for small-molecule cancer therapeutics is probably best illustrated by the efficacy of the drug Gleevec. In spite of this, the function of many of the kinases in the mammalian genome remains unknown. In a recent paper, MacKeigan and colleagues report a functional genetic screen using RNA interference to identify kinases and phosphatases involved in programmed cell death (). Functional annotation is a prerequisite for selection of new drug targets. Such studies may therefore lay the foundation for the next generation of cancer drugs.

机译：激酶家族作为小分子癌症治疗靶标的成功可能最好地通过药物格列卫的功效来说明。尽管如此，哺乳动物基因组中许多激酶的功能仍然未知。在最近的一篇论文中，MacKeigan及其同事报告了利用RNA干扰进行功能性遗传筛查，以鉴定参与程序性细胞死亡的激酶和磷酸酶。功能注释是选择新药物靶标的先决条件。因此，此类研究可能为下一代抗癌药物奠定基础。

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《Cancer Cell》 |2005年第6期|共2页
作者
Bernards R;
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正文语种 eng
中图分类肿瘤学;
关键词
Phosphorylation; Cessation of life; Malignant Neoplasms; Gleevec; prerequisite; 磷酰化;

机译：磷酸化;终止生命;恶性肿瘤;格列卫;前提;磷酰化;

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专利

1. A functional approach to questions about life, death, and phosphorylation. [J] . Bernards R Cancer Cell . 2005,第6期

机译：一种有关生命，死亡和磷酸化问题的实用方法。
2. {OPEN} {QUESTIONS} {IN} {ORIGIN} {OF} LIFE: {EXPERIMENTAL} {STUDIES} {ON} {THE} {ORIGIN} {OF} {NUCLEIC} {ACIDS} {AND} {PROTEINS} {WITH} {SPECIFIC} {AND} {FUNCTIONAL} {SEQUENCES} {BY} A {CHEMICAL} {SYNTHETIC} {BIOLOGY} {APPROACH} [J] . Katarzyna Adamala, Fabrizio Anella, Rafal Wieczorek, Computational and Structural Biotechnology Journal . 2014,第14期

机译：{OPEN} {QUESTIONS} {IN} {ORIGIN} {OF}寿命：{EXPERIMENTAL} {STUDIES} {ON} {THE} {ORIGIN} {OF} {NUCLEIC} {ACIDS} {AND} {PROTINS} {特定} {和} {功能} {序列} {BY} {化学} {合成} {生物学} {方法}
3. The ?book of life? (Psalm 69:29) - a question of life or death? [J] . A Groenewald Verbum et Ecclesia . 2003,第1期

机译：《生命书》？（诗篇69:29）-关于生与死的问题？
4. LIFE AND DEATH: UNDERSTANDING FROM A SYSTEMS APPROACH [C] . Janette E. McDonald Proceedings of the 47th annual conference the International Society for the Systems Sciences (ISSS 2003): agoras of the global village . 2003

机译：生命与死亡：从系统方法上理解
5. A functional genomic approach based on shRNA-mediated gene silencing to delineate the role of NF-kappaB and cell death proteins in the survival and proliferation of KSHV associated primary effusion lymphoma cells. [D] . Ijantkar, Akshata. 2014

机译：一种基于shRNA介导的基因沉默的功能基因组学方法，用于描述NF-κB和细胞死亡蛋白在KSHV相关原发性淋巴瘤细胞存活和增殖中的作用。
6. Open questions in origin of life: experimental studies on the origin of nucleic acids and proteins with specific and functional sequences by a chemical synthetic biology approach [O] . Katarzyna Adamala, Fabrizio Anella, Rafal Wieczorek, 2014

机译：生命起源方面的悬而未决的问题：通过化学合成生物学方法对具有特定功能序列的核酸和蛋白质起源进行实验研究
7. A functional approach to questions about life, death, and phosphorylation [O] . Bernards René 2005

机译：一种有关生命，死亡和磷酸化问题的实用方法

A functional approach to questions about life, death, and phosphorylation.

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