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首页> 外文期刊>Metabolic brain disease >Meloxicam-loaded nanocapsules as an alternative to improve memory decline in an Alzheimer's disease model in mice: involvement of Na+, K+-ATPase
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Meloxicam-loaded nanocapsules as an alternative to improve memory decline in an Alzheimer's disease model in mice: involvement of Na+, K+-ATPase

机译：装载美洛昔康的纳米胶囊可改善小鼠阿尔茨海默氏病模型的记忆衰退：Na +，K + -ATPase的参与

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The objective of this study was to investigate the effect of meloxicam-loaded nanocapsules (M-NC) on the treatment of the memory impairment induced by amyloid beta-peptide (a beta) in mice. The involvement of Na+, K+-ATPase and cyclooxygenase-2 (COX-2) activities in the hippocampus and cerebral cortex was also evaluated. Mice received a beta (3 nmol/ 3 mu l/ per site, intracerebroventricular) or vehicle (3 mu l/ per site, i.c.v.). The next day, the animals were treated with blank nanocapsules (17 mL/kg) or M-NC (5 mg/kg) or free meloxicam (M-F) (5 mg/kg). Treatments were performed every other day, until the twelfth day. Animals were submitted to the behavioral tasks (open-field, object recognition, Y-maze and step-down inhibitory avoidance tasks) from the twelfth day. Na+, K+-ATPase and COX-2 activities were performed in hippocampus and cerebral cortex. a beta caused a memory deficit, an inhibition of the hippocampal Na+, K+-ATPase activity and an increase in the hippocampal COX-2 activity. M-NC were effective against all behavioral and biochemical alterations, while M-F restored only the COX-2 activity. In conclusion, M-NC were able to reverse the memory impairment induced by a beta, and Na+, K+-ATPase is involved in the effect of M-NC.
机译：这项研究的目的是研究美洛昔康纳米胶囊（M-NC）对小鼠淀粉样β肽（a beta）诱导的记忆障碍的治疗作用。还评估了海马和大脑皮层中Na +，K + -ATPase和环氧合酶2（COX-2）的活性。小鼠接受了beta（3 nmol / 3μl/每个位点，脑室内）或赋形剂（3μl/每个位点，i.c.v。）。第二天，用空白纳米胶囊（17 mL / kg）或M-NC（5 mg / kg）或游离美洛昔康（M-F）（5 mg / kg）处理动物。每隔一天进行治疗，直到第十二天。从第十二天起，将动物接受行为任务（开阔地带，物体识别，Y迷宫和降压抑制回避任务）。 Na +，K + -ATPase和COX-2活性在海马和大脑皮层中进行。 β会导致记忆力减退，抑制海马Na +，K + -ATPase活性，并增加海马COX-2活性。 M-NC对所有行为和生化改变均有效，而M-F仅恢复COX-2活性。总之，M-NC能够逆转β诱导的记忆障碍，并且Na +，K + -ATPase参与M-NC的作用。

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