Targeting HIF2 alpha in Clear-Cell Renal Cell Carcinoma

Ricketts Christopher J.; Crooks Daniel R.; Linehan W. Marston

首页> 外文期刊>Cancer Cell >Targeting HIF2 alpha in Clear-Cell Renal Cell Carcinoma

【24h】

Targeting HIF2 alpha in Clear-Cell Renal Cell Carcinoma

机译：在透明细胞肾细胞癌中靶向HIF2α

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

In two recent studies, the HIF2 alpha antagonist, PT2399, decreased HIF2 alpha-dependent transcription and tumor growth in selected VHL-deficient clear-cell renal cell carcinoma (ccRCC) models. These studies validate HIF2 alpha as a therapeutic target in ccRCC, reveal variable sensitivity to HIF2 alpha antagonism, and provide the foundation for predictive biomarker-driven clinical trials.

机译：在两项最新研究中，在选定的VHL缺陷型透明细胞肾细胞癌（ccRCC）模型中，HIF2α拮抗剂PT2399降低了HIF2α依赖性转录和肿瘤生长。这些研究证实了HIF2 alpha作为ccRCC的治疗靶标，揭示了对HIF2 alpha拮抗作用的可变敏感性，并为预测性生物标志物驱动的临床试验提供了基础。

著录项

来源
《Cancer Cell》 |2016年第4期|共3页
作者
Ricketts Christopher J.; Crooks Daniel R.; Linehan W. Marston;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词

相似文献

外文文献
中文文献
专利

1. Targeting HIF2 alpha in Clear-Cell Renal Cell Carcinoma [J] . Ricketts Christopher J., Crooks Daniel R., Linehan W. Marston Cancer Cell . 2016,第4期

机译：在透明细胞肾细胞癌中靶向HIF2α
2. Hypoxia-Induced SUMOylation of E3 Ligase HAF Determines Specific Activation of HIF2 in Clear-Cell Renal Cell Carcinoma [J] . Koh Mei Yee, Vuvi Nguyen, Lemos Robert Jr., Cancer research: The official organ of the American Association for Cancer Research, Inc . 2015,第2期

机译：缺氧诱导的E3连接酶HAF的SUMOylation确定透明细胞肾细胞癌中HIF2的特异性激活
3. Effects of HIF-1 α and HIF2 α on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts [J] . Swethajit Biswas, Helen Troy, Russell Leek, Journal of oncology . 2010,第RegulaaissaartiaaPta1期

机译：HIF-1α和HIF2α对透明细胞肾细胞癌786-0异种移植物生长和代谢的影响
4. Application of High-Throughput Sequencing Data Mining in Comparison of Gene Expression Profile in Renal Cell Carcinoma and Normal Renal Cell by RNA-Seq [C] . Yunhai Yu, Hongmei Xu, Shaoning Guo, International Conference on Innovative Computing . 2020

机译：高通量测序数据挖掘在RNA-SEQ肾细胞癌和正常肾细胞中基因表达谱的比较中的应用
5. The roles of HIF1-alpha and target gene NDUFA4L2 in clear cell renal cell carcinoma [D] . Minton, Denise R. 2015

机译：HIF1-alpha和靶基因NDUFA4L2在透明细胞肾细胞癌中的作用
6. Effects of HIF-1α and HIF2α on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts [O] . Swethajit Biswas, Helen Troy, Russell Leek, 2010

机译：HIF-1α和HIF2α对肾透明细胞癌786-0异种移植物生长和代谢的影响
7. Effects of HIF-1 and HIF2 on growth and metabolism of clear-cell renal cell carcinoma 786-0 xenografts [O] . Stubbs M, Biswas S, Troy H, 2010

机译：HIF-1和HIF2对透明细胞肾细胞癌786-0异种移植物生长和代谢的影响

Targeting HIF2 alpha in Clear-Cell Renal Cell Carcinoma

摘要

著录项

相似文献

相关主题

期刊订阅