Mismatch repair proteins as sensors of alkylation DNA damage.

Wang JY; Edelmann W

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Mismatch repair proteins as sensors of alkylation DNA damage.

机译：错配的修复蛋白可作为烷基化DNA损伤的传感器。

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The DNA mismatch repair (MMR) system maintains genome integrity by correcting replication errors. MMR also stimulates checkpoint and cell death responses to DNA damage suggested by the resistance of MMR-defective tumor cells to several chemotherapeutic agents. MMR-dependent cytotoxic response may result from futile repair; however, MMR-mediated apoptosis has been genetically separated from its repair function. In a recent issue of Molecular Cell, Yoshioka and coworkers show that MMR complexes (MutSalpha and MutLalpha) are required for the recruitment of ATR-ATRIP to sites of alkylation damage, demonstrating that MMR complexes can function as sensors in DNA damage signal transduction.

机译：DNA错配修复（MMR）系统通过纠正复制错误来维持基因组完整性。 MMR还刺激针对DNA损伤的检查点和细胞死亡反应，这是MMR缺陷型肿瘤细胞对几种化学治疗剂的抗性所暗示的。无效的修复可能导致MMR依赖性细胞毒性反应;然而，MMR介导的细胞凋亡已从其修复功能上遗传分离。在最近一期的《分子细胞》中，吉冈及其同事表明，将ATR-ATRIP募集到烷基化损伤位点需要MMR复合物（MutSalpha和MutLalpha），这表明MMR复合物可以充当DNA损伤信号转导的传感器。

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《Cancer Cell》 |2006年第6期|共2页
作者
Wang JY; Edelmann W;
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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Measles-Mumps-Rubella Vaccine; DNA Damage; Alkylation; Proteins; physiological aspects; DNA损伤; 烷化作用; 蛋白质类;

机译：Measles-Mumps-Rubella Vaccine;DNA Damage;Alkylation;Proteins;physiological aspects;DNA损伤;烷化作用;蛋白质类;

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专利

1. 原发与复发性成胶质细胞瘤中 DNA错配修复蛋白、p53蛋白表达和 DNA倍性的差异 [J] . 谢丹, 王海军, 文剑明, 癌症（英文版） . 2001,第010期
2. Mismatch repair proteins as sensors of alkylation DNA damage. [J] . Wang JY, Edelmann W Cancer Cell . 2006,第6期

机译：错配的修复蛋白可作为烷基化DNA损伤的传感器。
3. Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage. [J] . Ning Ding, Emily M Bonham, Brooke E Hannon, Journal of molecular cell biology . 2016,第3期

机译：错配修复蛋白将DNA甲基转移酶1募集到氧化DNA损伤的位点。
4. Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage. [J] . Mastrocola AS, Heinen CD DNA repair . 2010,第2期

机译：DNA错配修复蛋白的核重组响应DNA损伤。
5. Limited Proteolysis and Oxidative Surface Mapping for Characterization of the DNA-Binding Domain of Mismatch Repair Protein Pms1 by Mass Spectrometry [C] . Allison N. Schorzman, Jenny M. Cutalo, Lars C. Pedersen, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：有限的蛋白水解和氧化表面映射，用于表征错配修复蛋白PMS1的DNA结合结构域通过质谱法
6. Generation of site-specific DNA-polypeptide cross-links mediated by Schiff base chemistry: A novel strategy to investigate the cellular pathways that repair DNA-protein cross-link damage. [D] . Kurtz, Andrew James. 2003

机译：由席夫碱化学介导的位点特异性DNA多肽交联的生成：研究修复DNA蛋白质交联损伤的细胞途径的新策略。
7. Activity and regulation of archaeal DNA alkyltransferase. CONSERVED PROTEIN INVOLVED IN REPAIR OF DNA ALKYLATION DAMAGE. [O] . Giuseppe Perugino, Antonella Vettone, Giuseppina Illiano, 2015

机译：古细菌DNA烷基转移酶的活性和调节。修复DNA烷基化损伤中涉及的保守蛋白。
8. Mismatch repair proteins as sensors of alkylation DNA damage [O] . Wang Jean Y.J., Edelmann Winfried 2006

机译：错配的修复蛋白可作为烷基化DNA损伤的传感器
9. Role of Cell Cycle Regulation and MLH1, A Key DNA Mismatch Repair Protein, In211 Adaptive Survival Responses. Final Report [R] . Boothman, D. A. 1999

机译：细胞周期调节和mLH1，关键DNa错配修复蛋白，In211适应性生存反应的作用。总结报告

Mismatch repair proteins as sensors of alkylation DNA damage.

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