Antibodies as Specific Chaperones

D.N.Ermolenko; A.V.Zherdev; B.B.Dzantiev

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Antibodies as Specific Chaperones

机译：作为特异性伴侣蛋白的抗体

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Protein folding is often accompanied by formation of non-native conformations leading to protein aggregation.A number of reports indicate that antibodies can facilitate folding and prevent aggregation of protein antigens.The influence of antibodies on folding is strictly antigen specific.Chaperone-like antibody activity may be due to the stabilization of native antigen conformations or folding transition states,or screening of aggregating hydrophobic surfaces.Taking advantage of chaperone-like activity of antibodies for immunotherapy may prove to be a promising approach to the treatment of Alzheimer's and prion-related diseases.Antibody-assisted folding may enhance renaturation of recombinant proteins from inclusion bodies.

机译：蛋白质折叠通常伴随着非天然构象的形成，从而导致蛋白质聚集。许多报告表明抗体可以促进折叠并阻止蛋白质抗原的聚集。抗体对折叠的影响严格是抗原特异性的。可能是由于天然抗原构象或折叠过渡状态的稳定化，或者是由于疏水表面的筛选所致。利用分子伴侣类似物的抗体进行免疫治疗可能被证明是治疗阿尔茨海默氏症和病毒相关疾病的一种有前途的方法抗体辅助折叠可增强包涵体重组蛋白的复性。

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来源
《Biochemistry》 |2004年第11期|共6页
作者
D.N.Ermolenko; A.V.Zherdev; B.B.Dzantiev;
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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
antibodies; protein aggregation; folding; chaperones; inclusion bodies;

机译：抗体;蛋白质聚集;折叠;伴侣蛋白;包涵体;

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1. Functional Production and Characterization of a Fibrin-Specific Single-Chain Antibody Fragment from Bacillus subtilis: Effects of Molecular Chaperones and a Wall-Bound Protease on Antibody Fragment Production [J] . Sau-Ching Wu, Jonathan C. Yeung, Yanjun Duan, Applied and Environmental Microbiology . 2002,第7期

机译：枯草芽孢杆菌纤维蛋白特异性单链抗体片段的功能生产和表征：分子伴侣和壁蛋白酶对抗体片段生产的影响。
2. Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention. [J] . Taner SB, Pando MJ, Roberts A, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2011,第1期

机译：NK细胞受体KIR3DL1 * 004与分子伴侣和构象特异性抗体的相互作用揭示了功能性折叠状态以及主要的细胞内保留。
3. Interactions of NK Cell Receptor KIR3DL1*004 with Chaperones and Conformation-Specific Antibody Reveal a Functional Folded State As Well As Predominant Intracellular Retention [J] . Sabrina B. Taner, Marcelo J. Pando, Allison Roberts, The journal of immunology . 2011,第1期

机译：NK细胞受体KIR3DL1 * 004与分子伴侣和构象特异性抗体的相互作用揭示了功能性折叠状态以及主要的细胞内保留
4. Human Synthetic, Semi-Synthetic, and Na?ve Immune Libraries for Efficient Isolation of Antigen Specific Antibodies Isolation of Antigen Specific Antibodies [C] . Man-Seok Ju, Sang Taek Jung PEGS . 2016

机译：人合成，半合成和Na ve've免疫文库，用于有效地分离抗原特异性抗体的分离分离抗原特异性抗体
5. Antibodies as RNA crystallization chaperones. [D] . Huang, Hao. 2015

机译：抗体为RNA结晶伴侣。
6. Functional Production and Characterization of a Fibrin-Specific Single-Chain Antibody Fragment from Bacillus subtilis: Effects of Molecular Chaperones and a Wall-Bound Protease on Antibody Fragment Production [O] . Sau-Ching Wu, Jonathan C. Yeung, Yanjun Duan, 2002

机译：枯草芽孢杆菌纤维蛋白特异性单链抗体片段的功能生产和表征：分子伴侣和壁蛋白酶对抗体片段生产的影响。
7. Functional Production and Characterization of a Fibrin-Specific Single-Chain Antibody Fragment from Bacillus subtilis: Effects of Molecular Chaperones and a Wall-Bound Protease on Antibody Fragment Production [O] . Wu, Sau-Ching, Yeung, Jonathan C., Duan, Yanjun, 2002

机译：枯草芽孢杆菌纤维蛋白特异性单链抗体片段的功能生产和表征：分子伴侣和壁蛋白酶对抗体片段生产的影响。

Antibodies as Specific Chaperones

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