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Computer-Aided Analysis of Spatial Structure of Some Hydrolytic Enzymes

机译:某些水解酶空间结构的计算机辅助分析

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摘要

Using the MolScript version 2.1 computer program for protein molecule modeling and X-ray structure analysis data the spatial structures of several hydrolytic enzymes have been compared.These include glucoamylase from Aspergillus awamori and Saccharomycopsis fibuligera and lipases from Rhizopus japonicus.Results on homology of amino acid sequences and topology of secondary structure elements were obtained.3D models of these enzymes with positioning of functionally important groups in the active site cavity were built.
机译:使用MolScript 2.1版计算机程序进行蛋白质分子建模和X射线结构分析数据,比较了几种水解酶的空间结构,其中包括泡盛曲霉和小球菌的葡糖淀粉酶以及日本根霉的脂肪酶。氨基酸同源性结果获得了二级结构元件的序列和拓扑。建立了这些酶的3D模型,并在活性位点腔中定位了功能重要的基团。

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