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首页> 外文期刊>Mechanisms of Ageing and Development >Takeout-dependent longevity is associated with altered Juvenile Hormone signaling
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Takeout-dependent longevity is associated with altered Juvenile Hormone signaling

机译：外卖依赖的寿命与少年激素信号改变有关

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摘要

In order to understand the molecular mechanisms of longevity regulation, we recently performed a screen designed to enrich for genes common to several longevity interventions. Using this approach, we identified the Drosophila melanogaster gene takeout. takeout is upregulated in a variety of long-lived flies, and extends life span when overexpressed. Here, we investigate the mechanisms of takeout-dependent longevity.takeout overexpression specifically in the fat body is sufficient to increase fly longevity and is additive to the longevity effects of Dietary Restriction. takeout long-lived flies do not show phenotypes often associated with increased longevity, such as enhanced stress resistance or major metabolic abnormalities. However, males exhibit greatly diminished courtship behavior, leading to a reduction in fertility. Interestingly, takeout contains a binding domain for Juvenile Hormone, a fly hormone that plays a role in the regulation of developmental transitions. Importantly, the longevity and courtship phenotypes of takeout overexpressing flies are reversed by treatment with the Juvenile Hormone analog methoprene.These data suggest that takeout is a key player in the tradeoff-switch between fertility and longevity. takeout may control fertility via modulation of courtship behavior. This regulation may occur through Juvenile Hormone binding to takeout and a subsequent reduction in Juvenile Hormone signaling activity.
机译：为了了解长寿调节的分子机制，我们最近进行了一次筛选，旨在丰富一些长寿干预措施共有的基因。使用这种方法，我们确定了果蝇果蝇基因外卖。外卖在各种长寿命的果蝇中被上调，过表达时可延长寿命。在这里，我们研究了依赖外卖的寿命的机制。外卖在脂肪体内的过度表达足以增加果蝇的寿命，并增加了饮食限制的寿命。外卖长寿果蝇没有表现出通常与长寿增加相关的表型，例如增强的抗逆性或重大的代谢异常。但是，男性的求偶行为大大减少，导致生育能力下降。有趣的是，外卖含有少年荷尔蒙的结合域，少年荷尔蒙是一种在发育发育调控中起作用的果蝇激素。重要的是，外卖过剩果蝇的长寿和求爱表型可以通过少年荷尔蒙类似物甲基异戊二烯的治疗来逆转，这些数据表明外卖是生育率和长寿之间权衡转换的关键因素。外卖可以通过调节求爱行为来控制生育。该调节可通过少年激素与外卖的结合以及随后少年激素信号传导活性的降低而发生。

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