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首页> 外文期刊>Medecine et maladies infectieuses >Ertapenem administered intravenously or subcutaneously for urinary tract infections caused by ESBL producing enterobacteriacea [Ertapénem intraveineux ou sous-cutané pour le traitement des infections urinaires à entérobactérie sécrétrice de BLSE]
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Ertapenem administered intravenously or subcutaneously for urinary tract infections caused by ESBL producing enterobacteriacea [Ertapénem intraveineux ou sous-cutané pour le traitement des infections urinaires à entérobactérie sécrétrice de BLSE]

机译：厄他培南静脉内或皮下给药治疗由ESBL产生肠杆菌引起的尿路感染

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Introduction: Ertapenem could be used to treat urinary tract infections (UTI) caused by ESBL producing enterobacteriacae (ESBL-E) and administered subcutaneously. Method: The authors made a retrospective study on adult patients treated with ertapenem administered intravenously or subcutaneously for UTI caused by ESBL-E, between May 2009 and August 2011 at the Chambery hospital, France. Results: Twenty-five patients were treated (13 cases of prostatitis, ten of pyelonephritis, two of cystitis) mostly caused by Escherichia coli (24 cases). Subcutaneous injections were administered to 20 patients and 23 were treated through outpatient parenteral antibiotic therapy (OPAT). All patients were cured at the end of the ertapenem therapy. Urine samples collected during treatment for 12 patients were sterile. Three months after the end of the treatment, five patients had relapsed, and six had developed a UTI caused by another bacteria. Conclusion: Ertapenem administered intravenously or subcutaneously could be an effective treatment for UTI caused by ESBL-E, especially using OPAT.
机译：简介：厄他培南可用于治疗由产生ESBL的肠杆菌（ESBL-E）引起的泌尿道感染（UTI）并皮下给药。方法：作者回顾性研究了2009年5月至2011年8月在法国尚贝里医院接受ESTA-E引起的静脉注射或皮下注射ertapenem治疗的成人患者的UTI的成年患者。结果：25例患者（其中前列腺炎13例，肾盂肾炎10例，膀胱炎2例）主要由大肠杆菌引起（24例）。皮下注射给药于20例患者，其中23例通过门诊肠胃外抗生素治疗（OPAT）治疗。在厄他培南治疗结束时所有患者均治愈。治疗期间为12例患者收集的尿液样本是无菌的。治疗结束三个月后，五名患者复发，六名患者出现了另一种细菌引起的尿路感染。结论：静脉注射或皮下注射厄他培南可有效治疗ESBL-E引起的UTI，尤其是使用OPAT。

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