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首页> 外文期刊>Medecine et maladies infectieuses >False-positive pneumococcal antigen test in a case of Enterococcus faecalis meningitis
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False-positive pneumococcal antigen test in a case of Enterococcus faecalis meningitis

机译：粪肠球菌脑膜炎一例假阳性肺炎球菌抗原检测

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摘要

Streptococcus pneumoniae is the leading cause of community-acquired pneumonia [1]. When not properly diagnosed and treated, S. pneumoniae infection can lead to potentially life-threatening meningitis, bacteremia, and pur-pura fulminans [1]. Pneumococcal meningitis can occur as a complication of other pneumococcal infections or may arise spontaneously without any other infection [2]. It most commonly affects children under 5 years of age, teenagers, young adults, and elderly patients [2]. Progression from mild illness to coma can occur within hours, making immediate diagnosis and antimicrobial treatment critical. The case fatality rate is 30%, often despite several days of appropriate antibiotic treatment .The Binax NOW? Streptococcus pneumoniae Antigen Card (Alere?, Jouy-en-Josas, France) is an in vitro rapid and simple immunochromatographic (ICT) membrane assay for the detection of S. pneumoniae soluble antigen (by rabbit anti-5. pneumoniae antibodies adsorbed onto nitrocellulose membrane) in the urine of patients with pneumonia and in the cerebral spinal fluid (CSF) of patients with meningitis [3,4]. It is intended, along with culture and other methods, to help diagnose both pneumococcal pneumonia and meningitis.The specificity of the test was 99-100%, and sensitivity 95-99% in 2 studies including 1692 patients among whom 91 presented with pneumococcal meningitis [5,6]. The French Society of Infectiology recommends performing this test on CSF when the clinical context is strongly suggestive of bacterial meningitis, and especially when direct examination is negative We report here a false-positive Binax NOW? Streptococcus pneumoniae test on the CSF of a patient with Enterococcus faecalis infective endocarditis complicated by meningitis.
机译：肺炎链球菌是社区获得性肺炎的主要原因[1]。如果未得到正确的诊断和治疗，肺炎链球菌感染可能导致潜在的威胁生命的脑膜炎，菌血症和暴发性紫癜[1]。肺炎球菌性脑膜炎可以与其他肺炎球菌感染并发，也可以在没有其他感染的情况下自发发生[2]。它最常影响5岁以下的儿童，青少年，年轻人和老年患者[2]。从轻度疾病到昏迷的进展可能会在数小时内发生，这使得立即诊断和抗菌治疗至关重要。尽管经过数天的适当抗生素治疗，但病死率仍高达30％。肺炎链球菌抗原卡（法国，Jouy-en-Josas的Alere？）是一种体外快速简便的免疫层析（ICT）膜测定法，用于检测肺炎链球菌可溶性抗原（通过吸附在硝酸纤维素上的兔抗5.肺炎球菌抗体）肺炎患者尿液中和脑膜炎患者脑脊髓液（CSF）中的含量[3,4]。它旨在与文化和其他方法一起帮助诊断肺炎球菌性肺炎和脑膜炎。在2项研究中，该试验的特异性为99-100％，敏感性为95-99％，其中包括1692例患者，其中91例患有肺炎球菌性脑膜炎[5,6]。法国传染病学会建议，如果临床情况强烈提示细菌性脑膜炎，尤其是直接检查为阴性时，应在脑脊液中进行此项检查。粪肠球菌感染性心内膜炎并发脑膜炎患者脑脊液的肺炎链球菌检测。

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