Inhibiting protein-protein interactions as an emerging paradigm for drug discovery.

Gerrard JA; Hutton CA; Perugini MA

首页> 外文期刊>Mini reviews in medicinal chemistry >Inhibiting protein-protein interactions as an emerging paradigm for drug discovery.

【24h】

Inhibiting protein-protein interactions as an emerging paradigm for drug discovery.

机译：抑制蛋白质间相互作用是药物发现的新兴范例。

获取原文

获取原文并翻译 | 示例

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Association of proteins into homo- and hetero-oligomers plays an important role in a plethora of biological phenomena. Inhibition of these interactions is increasingly recognized as a valuable new direction in drug design. In this mini-review we consider inhibition of protein misfolding and aggregation, molecules that disrupt enzyme quaternary structure, and signaling inhibitors, as emerging drugs.

机译：蛋白质缔合为同型和异型寡聚体在众多生物学现象中起着重要作用。抑制这些相互作用已日益被认为是药物设计中有价值的新方向。在本微型综述中，我们将抑制蛋白质错误折叠和聚集，破坏酶季结构的分子以及信号抑制剂作为新兴药物。

著录项

来源
《Mini reviews in medicinal chemistry》 |2007年第2期|共7页
作者
Gerrard JA; Hutton CA; Perugini MA;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Drug Design; Proteins; 蛋白质类;

机译：Drug Design;Proteins;蛋白质类;

相似文献

外文文献
中文文献
专利

1. Inhibiting protein-protein interactions as an emerging paradigm for drug discovery. [J] . Gerrard JA, Hutton CA, Perugini MA Mini reviews in medicinal chemistry . 2007,第2期

机译：抑制蛋白质间相互作用是药物发现的新兴范例。
2. Inhibiting Protein-Protein Interactions as an Emerging Paradigm for Drug Discovery [J] . J. A. Gerrard C. A. Hutton M. A. Perugini Mini-Reviews in Medicinal Chemistry . 2007,第2期

机译：抑制蛋白质-蛋白质相互作用作为药物发现的新兴范例
3. Editorial [Hot Topic: Small Molecule Inhibition of Protein-Protein Interaction:An Emerging Paradigm in Drug Design (Guest Editor: Craig W. Lindsley)] [J] . Craig W. Lindsley Current Topics in Medicinal Chemistry . 2007,第10期

机译：社论[热门话题：蛋白质-蛋白质相互作用的小分子抑制：药物设计的新兴范例（来宾编辑：Craig W. Lindsley）
4. Improving Distantly Supervised Extraction of Drug-Drug and Protein-Protein Interactions [C] . Tamara Bobic, Roman Klinger, Philippe Thomas, Joint workshop on unsupervised and semi-supervised learning in NLP 2012 . 2012

机译：改善对药物和蛋白质-蛋白质相互作用的监督提取
5. Toward Better Development of Protein-Protein Interaction Inhibitors: Applications to the beta-Catenin/T-Cell Factor Protein-Protein Interaction [D] . Catrow, Jonathan Leon. 2017

机译：寻求更好的蛋白质-蛋白质相互作用抑制剂的开发：在β-Catenin/ T细胞因子蛋白质-蛋白质相互作用中的应用
6. Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions [O] . Rebecca R. Crawford, Praveen K. Potukuchi, Erin G. Schuetz, -1

机译：超越竞争性抑制：激酶和蛋白质-蛋白质相互作用作为药物-药物相互作用的潜在机制对ABC转运蛋白的调控
7. Optimizing Classification of Drug-Drug Interaction Potential for CYP450 Iso-Enzymes Inhibition Assays in Early Drug Discovery. [O] . Krippendorff, Ben-Fillippo, Lienau, Philip, Reichel, Andreas, 2007

机译：CYP450同工酶抑制试验中早期药物发现的药物相互作用潜力的优化分类。
8. Cross-species Virus-host Protein-Protein Interactions Inhibiting Innate Immunity. [R] . Umland, T. C. 2016

机译：跨物种病毒 - 宿主蛋白质 - 蛋白质相互作用抑制先天免疫。

Inhibiting protein-protein interactions as an emerging paradigm for drug discovery.

摘要

著录项

相似文献

相关主题

期刊订阅