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首页> 外文期刊>International journal of urology: official journal of the Japanese Urological Association >Identification of autoantibodies elicited in a patient with prostate cancer presenting as dermatomyositis.
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Identification of autoantibodies elicited in a patient with prostate cancer presenting as dermatomyositis.

机译：鉴定为表现为皮肌炎的前列腺癌患者体内引起的自身抗体。

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OBJECTIVES: Dermatomyositis is an uncommon autoimmune disease distinguished by proximal muscle weakness and a characteristic skin rash. Dermatomyositis has also frequently been associated with malignancy, typically heralding the diagnosis of ovarian, lung, gastric, or colorectal cancer. We report an unusual case of prostate adenocarcinoma preceded by a diagnosis of dermatomyositis. We hypothesized that in this particular patient, proteins produced by the neoplastic prostatic tissue, which might be normally expressed in muscle tissue, were immunologically recognized as autoantigens. METHODS: Serum from this patient was used to screen a cDNA lambda phage expression library from normal prostate tissue for prostate protein-specific IgG. RESULTS: We identified several immunoreactive plaques encoding known autoantigens, and several encoding known muscle-related proteins, including aldolase C, eukaryotic translation elongation factor 1 alpha 1, transgelin, and acetyl-coenzyme A acyltransferase 1. IgG specific for these proteins were not specifically recognized in sera from other patients with prostate cancer compared with male control blood donors, and were not specifically recognized in a small panel of sera from patients with breast or ovarian cancer and dermatomyositis. CONCLUSIONS: Our results demonstrate that this patient with prostate cancer presenting as dermatomyositis had autoantibodies to specific proteins, possibly associated with his autoimmune myopathy. Moreover, given this patient's history and the multiple treatment options for prostate cancer, the identification of dermatomyositis in men should prompt an evaluation to exclude a concurrent diagnosis of prostate cancer.
机译：目的：皮肌炎是一种罕见的自身免疫性疾病，以近端肌肉无力和特征性皮疹为特征。皮肌炎也经常与恶性肿瘤相关，通常预示着卵巢癌，肺癌，胃癌或结直肠癌的诊断。我们报告了一个罕见的前列腺腺癌病例，随后诊断为皮肌炎。我们假设在该特定患者中，由肿瘤性前列腺组织产生的蛋白质可能会在肌肉组织中正常表达，因此在免疫学上被视为自身抗原。方法：使用该患者的血清从正常前列腺组织中筛选λ噬菌体的cDNA表达，以检测前列腺蛋白特异性IgG。结果：我们鉴定出几种编码已知自身抗原的免疫反应斑块，以及几种编码已知肌肉相关蛋白的蛋白，包括醛缩酶C，真核翻译延伸因子1α1，转胶蛋白和乙酰辅酶A酰基转移酶1。与男性对照献血者相比，在其他前列腺癌患者的血清中可识别出血清，但在乳腺癌，卵巢癌和皮肌炎患者的一小部分血清中并未特异性识别。结论：我们的结果表明，这例表现为皮肌炎的前列腺癌患者具有针对特定蛋白质的自身抗体，可能与自身免疫性肌病有关。此外，鉴于该患者的病史和前列腺癌的多种治疗选择，对男性皮肌炎的鉴定应促使进行评估以排除对前列腺癌的同时诊断。

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