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首页> 外文期刊>Cancer letters >A novel role of EMMPRIN/CD147 in transformation of quiescent fibroblasts to cancer-associated fibroblasts by breast cancer cells
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A novel role of EMMPRIN/CD147 in transformation of quiescent fibroblasts to cancer-associated fibroblasts by breast cancer cells

机译：EMMPRIN / CD147在乳腺癌细胞将静止的成纤维细胞转化为癌症相关的成纤维细胞中的新作用

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摘要

We tested the novel hypothesis that EMMPRIN/CD147, a transmembrane glycoprotein overexpressed in breast cancer cells, has a previously unknown role in transforming fibroblasts to cancer-associated fibroblasts, and that cancer-associated fibroblasts in turn induce epithelial-to-mesenchymal transition of breast cancer cells. Co-culture of fibroblasts with breast cancer cells or treatment of fibroblasts with breast cancer cell conditioned culture medium or recombinant EMMPRIN/CD147 induced expression of α-SMA in the fibroblasts in an EMMPRIN/CD147-dependent manner and promoted epithelial-to-mesenchymal transition of breast cancer cells and enhanced cell migration potential. These findings support a novel role of EMMPRIN/CD147 in regulating the interaction between cancer and stroma.
机译：我们测试了新的假设，即EMMPRIN / CD147，一种在乳腺癌细胞中过表达的跨膜糖蛋白，在将成纤维细胞转化为癌症相关的成纤维细胞方面具有未知的作用，而与癌症相关的成纤维细胞反过来又诱导了乳腺癌的上皮-间质转化。癌细胞。成纤维细胞与乳腺癌细胞共培养或用乳腺癌细胞条件培养基或重组EMMPRIN / CD147处理成纤维细胞以EMMPRIN / CD147依赖性方式诱导成纤维细胞中α-SMA的表达并促进上皮向间充质转化乳腺癌细胞和增强的细胞迁移潜力。这些发现支持EMMPRIN / CD147在调节癌症与基质之间的相互作用中的新作用。

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