Practical and low cost whole-organism motility assay: A step-by-step protocol

Preston Sarah; Jabbar Abdul; Nowell Cameron; Joachim Anja; Ruttkowski Baerbel; Cardno Tony; Hofmann Andreas; Gasser Robin B.

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Practical and low cost whole-organism motility assay: A step-by-step protocol

机译：实用且低成本的全生物动力测定：分步操作规程

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Here, we provide a step-by-step protocol for a practical and low cost whole-organism assay for the screening of chemical compounds for activity against parasitic worms. This assay has considerable advantages over conventional methods, mainly in relation to ease of use, throughput, time and cost. It is readily suited to the screening of hundreds to thousands of compounds for subsequent hit-to-lead optimisation, and should be applicable to many different parasites and other organisms commensurate with the size of wells in the microtiter plates used for phenotypic screening. (C) 2015 Elsevier Ltd. All rights reserved.

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《Molecular and Cellular Probes: The Location, Diagnosis and Monitoring of Disease by Specific Molecules and Cell Lines》 |2016年第1期|共5页
作者
Preston Sarah; Jabbar Abdul; Nowell Cameron; Joachim Anja; Ruttkowski Baerbel; Cardno Tony; Hofmann Andreas; Gasser Robin B.;
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正文语种 eng
中图分类诊断学;
关键词
Drug screening; Motility assay; Step-by-step protocol; Nematode; Parasite;

机译：药物筛选;动力分析;分步操作方案;线虫;寄生虫;

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1. Practical and low cost whole-organism motility assay: A step-by-step protocol [J] . Preston Sarah, Jabbar Abdul, Nowell Cameron, Molecular and Cellular Probes: The Location, Diagnosis and Monitoring of Disease by Specific Molecules and Cell Lines . 2016,第1期

机译：实用且低成本的全生物动力测定：分步操作规程
2. Extraction Protocols for Individual Zebrafish's Ventricle Myosin and Skeletal Muscle Actin for In vitro Motility Assays [J] . Lisa-Mareike Scheid, Cornelia Weber, Nasrin Bopp, Frontiers in Physiology . 2017,第10期

机译：斑马鱼心室肌球蛋白和骨骼肌肌动蛋白的提取方案用于体外运动测定
3. Extraction Protocols for Individual Zebrafish's Ventricle Myosin and Skeletal Muscle Actin for In vitro Motility Assays [J] . Lisa-Mareike Scheid, Cornelia Weber, Nasrin Bopp, Frontiers in Physiology . 2017,第8期

机译：斑马鱼心室肌球蛋白和骨骼肌肌动蛋白的提取方案用于体外运动测定
4. Determining Dose-Response Characteristics of Molecular Perturbations in Whole-Organism Assays Using Biological Imaging and Machine Learning [C] . Daniel Asarnow, Rahul Singh IEEE International Conference on Bioinformatics and Biomedicine . 2018

机译：使用生物成像和机器学习确定全有机物分析中分子扰动的剂量反应特征
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Practical and low cost whole-organism motility assay: A step-by-step protocol

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