MiR-21 functionally interacts with the 3'UTR of chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells

VicinusB.; RubieC.; FaustS.K.; FrickV.O.; GhadjarP.; WagnerM.; GraeberS.; SchillingM.K.

首页> 外文期刊>Cancer letters >MiR-21 functionally interacts with the 3'UTR of chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells

【24h】

MiR-21 functionally interacts with the 3'UTR of chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells

机译：MiR-21在功能上与趋化因子CCL20的3'UTR相互作用并下调miR-21转染的结直肠癌细胞中的CCL20表达

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

As deregulation of miRNAs and chemokine CCL20 was shown to play a role in colorectal cancer (CRC) pathogenesis, we analyzed the functional interactions of candidate miRNAs with CCL20 mRNA. After target prediction software programs indicated a role for miR-21 in CCL20 regulation, we applied the luciferase reporter assay system to demonstrate that miR-21 functionally interacts with the 3'UTR of CCL20 mRNA and down-regulates CCL20 in miR-21 mimic transfected CRC cell lines (Caco-2, SW480 and SW620). Thus, regulation of CCL20 expression by miR-21 might be a regulatory mechanism involved in progression of CRC.

机译：由于显示出miRNA和趋化因子CCL20的失调在结直肠癌（CRC）发病机理中起作用，我们分析了候选miRNA与CCL20 mRNA的功能相互作用。在目标预测软件程序表明miR-21在CCL20调控中发挥作用后，我们应用萤光素酶报告基因检测系统来证明miR-21在功能上与CCL20 mRNA的3'UTR相互作用，并下调miR-21模拟转染的CCL20。 CRC细胞系（Caco-2，SW480和SW620）。因此，miR-21对CCL20表达的调控可能是参与CRC进展的调控机制。

著录项

来源
《Cancer letters》 |2012年第1期|共8页
作者
VicinusB.; RubieC.; FaustS.K.; FrickV.O.; GhadjarP.; WagnerM.; GraeberS.; SchillingM.K.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
CCL20; Chemokines; CRC; MicroRNA; MiR-21;

机译：CCL20;趋化因子;CRC;MicroRNA;MiR-21;

相似文献

外文文献
中文文献
专利

1. MiR-21 functionally interacts with the 3'UTR of chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells [J] . VicinusB., RubieC., FaustS.K., Cancer letters . 2012,第1期

机译：MiR-21在功能上与趋化因子CCL20的3'UTR相互作用并下调miR-21转染的结直肠癌细胞中的CCL20表达
2. An autoregulatory feedback loop of miR-21/VMP1 is responsible for the abnormal expression of miR-21 in colorectal cancer cells [J] . Caixia Wang, Rui Peng, Min Zeng, Cell death & disease. . 2020,第12期

机译：miR-21 / VMP1的自动调节反馈回路是对直肠癌细胞中miR-21的异常表达的原因
3. MiR-21 is involved in cervical squamous cell tumorigenesis and regulates CCL20 [J] . YaoT., LinZ. Biochimica et biophysica acta. Molecular basis of disease: BBA . 2012,第2期

机译：MiR-21参与子宫颈鳞状细胞癌的发生并调节CCL20
4. ERβ regulates miR-21 expression and inhibits invasion and metastasis in cancer cells [C] . Junmei Tian, Zhenzhen Tu, Yueqing Gu Biophotonics and immune responses VII. . 2012

机译：ERβ调节miR-21表达并抑制癌细胞的侵袭和转移
5. Study of miR-21 and miR-221 Expression in Breast Cancer FFPE Tissue Sections by Real Time PCR and Chromogenic in situ Hybridization. [D] . Hug, Kelly A. 2013

机译：实时荧光定量PCR和发色原位杂交研究乳腺癌FFPE组织切片中miR-21和miR-221的表达。
6. C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release [O] . Helene Kolstad Skovdahl, Jan Kristian Damås, Atle van Beelen Granlund, 2018

机译：人外周血单个核细胞中的C-C母体配体20（CCL20）和C-C母体趋化因子受体6（CCR6）：在溃疡性结肠炎中失调并且CCL20在IL-1β释放中的潜在作用
7. MiR-21 is involved in cervical squamous cell tumorigenesis and regulates CCL20 [O] . Yao Tingting, Lin Zhongqiu 2012

机译：MiR-21参与子宫颈鳞状细胞癌的发生并调节CCL20

MiR-21 functionally interacts with the 3'UTR of chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells

摘要

著录项

相似文献

相关主题

期刊订阅