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首页> 外文期刊>Cancer letters >Immunospecific targeting of CD45 expressing lymphoid cells: Towards improved detection agents of the sentinel lymph node
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Immunospecific targeting of CD45 expressing lymphoid cells: Towards improved detection agents of the sentinel lymph node

机译：CD45表达淋巴样细胞的免疫特异性靶向：改进前哨淋巴结的检测剂

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This study was designed to demonstrate the potential of small nanoparticulate lymphotropic contrast agents designed to bind with high affinity to lymphoid cells overexpressing the CD45 antigen. To this end, small gold nanoparticles used as model were conjugated to anti-CD45 antibodies and injected in mice in the dorsal toe of the fore/hind paw. Chemical analysis demonstrated rapid uptake and transport of the nanoparticles in the lymphatic as well as significant retention of the nanoparticles with high binding affinity to lymphoid cells in the popliteal and axillary lymph nodes in comparison to non-targeted nanoparticles.
机译：这项研究旨在证明小型纳米颗粒淋巴造影剂的潜力，这些造影剂被设计为与过表达CD45抗原的淋巴细胞高亲和力结合。为此，将用作模型的小金纳米颗粒与抗CD45抗体偶联，并将其注射到前爪/后爪的背趾小鼠中。化学分析表明，与非靶向纳米颗粒相比，纳米颗粒在淋巴管中的快速摄取和运输以及与to，腋窝淋巴结中与淋巴样细胞具有高结合亲和力的纳米颗粒的显着保留。

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