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Targeting apoptosis pathways in childhood malignancies

机译:针对儿童恶性肿瘤的凋亡途径

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摘要

Evasion of apoptosis (programmed cell death) is a characteristic feature of human cancers including childhood malignancies. Since cytotoxic therapies such as chemotherapy or radiotherapy trigger apoptosis as a primary mechanism of action, resistance to apoptosis can also lead to treatment resistance. Studies on apoptosis pathways in childhood malignancies yielded a series of key molecules that can now be exploited as molecular targets for the development of targeted therapies. This strategy is anticipated to open novel perspectives for more effective treatment options for children with cancer.
机译:规避细胞凋亡(程序性细胞死亡)是包括儿童恶性肿瘤在内的人类癌症的特征。由于细胞毒性疗法(例如化学疗法或放射疗法)触发细胞凋亡作为主要作用机制,因此对细胞凋亡的抵抗力也可能导致治疗耐药性。对儿童恶性肿瘤中细胞凋亡途径的研究产生了一系列关键分子,这些关键分子现在可以用作开发靶向疗法的分子靶标。预期该策略将为癌症儿童的更有效治疗选择开辟新的前景。

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