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首页> 外文期刊>Cancer nursing >Vitamin D insufficiency and musculoskeletal symptoms in breast cancer survivors on aromatase inhibitor therapy.
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Vitamin D insufficiency and musculoskeletal symptoms in breast cancer survivors on aromatase inhibitor therapy.

机译：芳香化酶抑制剂治疗的乳腺癌幸存者中的维生素D功能不足和肌肉骨骼症状。

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摘要

Breast cancer survivors (BCSs) on aromatase inhibitor (AI) therapy often experience musculoskeletal symptoms (joint pain and stiffness, bone and muscle pain, and muscle weakness), and these musculoskeletal symptoms may be related to low serum levels of vitamin D. The primary purpose of this pilot exploratory study was to determine whether serum levels of 25-hydroxyvitamin D (25[OH]D) concentration were below normal (<30 ng/mL) in 29 BCSs on AI therapy and if musculoskeletal symptoms were related to these low vitamin D levels. The mean (SD) serum 25(OH)D level was 25.62 (4.93) ng/mL; 86% (n = 25) had levels below 30 ng/mL. Patients reported muscle pain in the neck and back, and there was a significant inverse correlation between pain intensity and serum 25(OH)D levels (r = -0.422; P < .05 [2 tailed]). This sample of BCSs taking AIs had below normal levels of serum 25(OH)D despite vitamin D supplements. This is one of the few studies to document a significant relationship between vitamin D levels and muscle pain in BCSs on AI therapy. Findings from this pilot study can be used to inform future studies examining musculoskeletal symptoms in BCSs on AI therapy and relationships with low serum levels of vitamin D.
机译：接受芳香化酶抑制剂（AI）治疗的乳腺癌幸存者（BCS）经常会出现肌肉骨骼症状（关节疼痛和僵硬，骨骼和肌肉疼痛以及肌肉无力），这些肌肉骨骼症状可能与维生素D的血清水平低有关。这项初步探索性研究的目的是确定接受AI治疗的29个BCS中血清25-羟基维生素D（25 [OH] D）浓度是否低于正常水平（<30 ng / mL），以及肌肉骨骼症状是否与这些低血压有关维生素D水平。血清25（OH）D的平均（SD）水平为25.62（4.93）ng / mL; 86％（n = 25）的水平低于30 ng / mL。患者报告颈部和背部肌肉疼痛，并且疼痛强度与血清25（OH）D水平呈显着负相关（r = -0.422; P <0.05）[2尾]。尽管补充了维生素D，但服用AIs的BCS样本的血清25（OH）D仍低于正常水平。这是在AI治疗中证明BCS中维生素D水平与肌肉疼痛之间显着关系的少数研究之一。这项前瞻性研究的结果可用于为将来的研究提供指导，探讨AI治疗中BCS中的肌肉骨骼症状以及与低血清维生素D的关系。

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