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Disruption of yeast forkhead-associated cell cycle transcription by oxidative stress

机译：氧化应激破坏酵母叉头相关细胞周期转录

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摘要

The effects of oxidative stress on yeast cell cycle depend on the stress-exerting agent. We studied the effects of two oxidative stress agents, hydrogen peroxide (HP) and the superoxide-generating agent menadione (MD). We found that two small coexpressed groups of genes regulated by the Mcm1-Fkh2-Ndd1 transcription regulatory complex are sufficient to account for the difference in the effects of HP and MD on the progress of the cell cycle, namely, G1 arrest with MD and an S phase delay followed by a G2/M arrest with HP. Support for this hypothesis is provided by fkh1fkh2 double mutants, which are affected by MD as we find HP affects wild-type cells. The apparent involvement of a forkhead protein in HP-induced cell cycle arrest, similar to that reported for Caenorhabditis elegans and human, describes a potentially novel stress response pathway in yeast.
机译：氧化应激对酵母细胞周期的影响取决于应激物质。我们研究了两种氧化应激剂，过氧化氢（HP）和超氧化物生成剂甲萘醌（MD）的作用。我们发现，由Mcm1-Fkh2-Ndd1转录调节复合物调节的两个基因的小共表达组足以说明HP和MD对细胞周期进展的影响的差异，即G1停滞与MD和S期延迟，然后被HP G2 / M逮捕。 fkh1fkh2双重突变体为这一假设提供了支持，因为我们发现HP会影响野生型细胞，因此它们会受到MD的影响。叉头蛋白明显参与了HP诱导的细胞周期停滞，这与秀丽隐杆线虫和人的报道相似，描述了酵母中潜在的新型应激反应途径。

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