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首页> 外文期刊>Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging >Early treatment response evaluation in patients with diffuse large B-cell lymphoma-A pilot study comparing volumetric MRI and PET/CT
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Early treatment response evaluation in patients with diffuse large B-cell lymphoma-A pilot study comparing volumetric MRI and PET/CT

机译：弥漫性大B细胞淋巴瘤患者的早期治疗反应评估-对比容积MRI和PET / CT的先导研究

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Purpose: The purpose of this study is to evaluate the time course of early chemotherapy response in patients with aggressive non-Hodgkin's lymphoma (NHL) by magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT). Procedures: Eight patients with histologically proven aggressive NHL were imaged by MRI and PET/CT before treatment (E1), 1 week (E2), and two cycles (E3) after chemotherapy. Results: The mean tumor volume on MRI was 276 mL at baseline; it decreased 58% at E2 (p≤0.05) and 65% further at E3 (p≤0.05), giving a total decrease of 84% (p≤0.05). All the imaged pre-therapy tumors were strongly positive on PET/CT, with a mean maximum standardized uptake value (SUV max) of 20. The SUV max decreased 60% at E2 (p≤0.05) and 59% further at E3 (p≤0.05), giving a total decrease of 83% (p≤0.05). The active tumor burden (mean 229 mL) decreased 66% at E2 (p≤0.05). The tumor volume on MRI correlated with the active tumor volume on fused PET/CT images in the same region of interest at both E1 and E2 (r=0.88, pG 0.01, respectively). Conclusions: Standard chemotherapy causes rapid decrease of both tumor metabolic activity and volume as early as 1 week, which continues to decline during therapy. Both volumetric MRI and PET/CT are valuable tools for early treatment response evaluation of aggressive NHL.
机译：目的：本研究的目的是通过磁共振成像（MRI）和正电子发射断层扫描/计算机断层扫描（PET / CT）评估侵袭性非霍奇金淋巴瘤（NHL）患者早期化疗反应的时间过程。程序：对8例经组织学证实为侵袭性NHL的患者在治疗前（E1），1周（E2）和化疗后两个周期（E3）进行MRI和PET / CT成像。结果：在基线时，MRI的平均肿瘤体积为276 mL;它在E2下降了58％（p≤0.05），在E3下降了65％（p≤0.05），总下降了84％（p≤0.05）。所有成像的治疗前肿瘤均在PET / CT上呈强阳性，平均最大标准摄取值（SUV max）为20。E2时SUV max降低60％（p≤0.05），E3时SUV max进一步降低59％（p≤0.05）。 ≤0.05），总共降低了83％（p≤0.05）。在E2时，活跃的肿瘤负荷（平均229 mL）减少了66％（p≤0.05）。 MRI上的肿瘤体积与E1和E2处相同目标区域中融合PET / CT图像上的活动肿瘤体积相关（r = 0.88，pG 0.01）。结论：标准化学疗法可导致肿瘤代谢活性和肿瘤体积在1周之内迅速下降，并在治疗过程中持续下降。体积MRI和PET / CT都是用于评估侵袭性NHL的早期治疗反应的有价值的工具。

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