...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging >68Ga-DOTA-TATE PET vs. 123I-MIBG in identifying malignant neural crest tumours
【24h】

68Ga-DOTA-TATE PET vs. 123I-MIBG in identifying malignant neural crest tumours

机译：68Ga-DOTA-TATE PET与123I-MIBG鉴别恶性神经c肿瘤

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: We aimed to compare imaging with 123I-MIBG and 68Ga-DOTA-TATE in neural crest tumours (NCT) to see if the latter could offer more advantage in detecting extra lesions and have higher sensitivity for malignant lesions. Procedures: We retrospectively reviewed 12 patients (M=10, F=2; age range 20-71 years) with NCT (phaeochromocytomas = 7, paragangliomas = 4, medullary thyroid cancer = 1) who underwent both 68Ga-DOTA-TATE positron emission tomography (PET) or PET/computed tomography (CT) and 123IMIBG single-photon emission computed tomography within 6months. Visual assessment of all lesions and measurement of targeton-target (T/N) ratio in selected lesions were performed. Five patients (aged 50 or less) had SDHB screening results correlated with imaging results of both radiopharmaceuticals. All patients had contrast-enhanced CT and/or other cross-sectional imaging. Results: 68Ga-DOTA-TATE PET showed tumour lesions in ten out of 12 patients with confirmed disease, while 123I-MIBG showed lesions in five out of 12 patients. In one patient, both 68Ga-DOTATATE PET and 123I-MIBG were negative, but CT,magnetic resonance imaging, and 2-deoxy-2-[18F] fluoro-D-glucose PET scans identified a lesion in the thorax. 68Ga-DOTA-TATE and 123I-MIBG detected a total of 30 lesions, of which 29/30 were positive with 68Ga-DOTA-TATE and 7/30 with 123I-MIBG. We also found higher incidence of SDHB positive results in patients with positive 68Ga-DOTA-TATE. Conclusion: Our limited data suggest that 68Ga-DOTA-TATE is a better imaging agent for NCT and detects significantly more lesions with higher T/Nratio compared to 123I- MIBG. 68Ga-DOTA-TATE was more likely to detect malignant lesions as indicated by correlating imaging results with SDHB screening.
机译：目的：我们旨在比较在神经neural瘤（NCT）中与123I-MIBG和68Ga-DOTA-TATE成像的比较，以了解后者在检测额外病变方面是否可以提供更多优势并且对恶性病变具有更高的敏感性。程序：我们回顾性回顾了均接受68Ga-DOTA-TATE正电子发射的12例NCT（嗜铬细胞瘤= 7，副神经节瘤= 4，甲状腺髓样癌= 1）的患者（M = 10，F = 2;年龄范围20-71岁）。断层扫描（PET）或PET /计算机断层扫描（CT）和123IMIBG单光子发射计算机断层扫描在6个月内。目视评估所有病变并测量所选病变中的靶标/非靶标（T / N）比。 5名患者（50岁或以下）的SDHB筛查结果与两种放射性药物的影像学检查结果均相关。所有患者均进行了对比增强的CT和/或其他横断面成像。结果：68Ga-DOTA-TATE PET在12例确诊疾病患者中有10例显示肿瘤病变，而123I-MIBG在12例患者中有5例显示病变。在一名患者中，68Ga-DOTATATE PET和123I-MIBG均为阴性，但CT，磁共振成像和2-deoxy-2- [18F]氟-D-葡萄糖PET扫描发现了胸腔中的病变。 68Ga-DOTA-TATE和123I-MIBG共检测到30个病灶，其中29/30为68Ga-DOTA-TATE和123I-MIBG为阳性。我们还发现68Ga-DOTA-TATE阳性的患者中SDHB阳性结果的发生率更高。结论：我们的有限数据表明68Ga-DOTA-TATE是一种更好的NCT成像剂，与123I-MIBG相比，具有更高的T / Nr比可检测到更多的病变。 68Ga-DOTA-TATE更有可能检测到恶性病变，如将影像学结果与SDHB筛查结果相关联。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号