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The Case for a Pre-Cancer Genome Atlas (PCGA)

机译：癌前基因组图谱（PCGA）的案例

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Understanding the earliest molecular and cellular events associated with cancer initiation remains a key bottleneck to transforming our approach to cancer prevention and detection. While TCGA has provided unprecedented insights into the genomic events associated with advanced stage cancer, there have been few studies comprehensively profiling premalignant and early-stage disease or elucidating the role of the microenvironment in premalignancy and tumor initiation. In this article, we make a call for development of a "Pre-Cancer Genome Atlas (PCGA)," a concerted initiative to characterize the molecular alterations in premalignant lesions and the corresponding changes in the microenvironment associated with progression to invasive carcinoma. This initiative will require a multicenter coordinated effort to comprehensively profile ( cellular and molecular) premalignant lesions and their corresponding "field of injury" collected longitudinally as the lesion progresses towards or regresses from frank malignancy across multiple tumor types. Genomic characterization of alterations in premalignant lesions and their microenvironment, for both bulk tissue and single cells, will enable development of biomarkers for early detection and risk stratification as well as allow for the development of novel targeted cancer interception strategies. The multi-institutional and multidisciplinary collaborative "big-data" effort underlying the PCGA will help usher in a new era of precision medicine for cancer detection and prevention. (C) 2016 AACR.
机译：了解与癌症发生有关的最早的分子和细胞事件仍然是转变我们预防和检测癌症方法的关键瓶颈。尽管TCGA对与晚期癌症有关的基因组事件提供了前所未有的见解，但很少有研究全面分析恶性前和早期疾病或阐明微环境在恶性前期和肿瘤发生中的作用。在本文中，我们呼吁开发“癌前基因组图谱（PCGA）”，这是一项共同行动，旨在表征癌前病变中的分子变化以及与进展为浸润性癌相关的微环境的相应变化。这项计划将需要多中心的共同努力，以全面剖析（细胞和分子）恶变前病变及其相应的“损伤区域”，这些病变是在病变向多种肿瘤类型的坦率恶性肿瘤进展或从其退步时纵向收集的。对于大块组织和单个细胞，癌前病变及其微环境改变的基因组学表征将有助于开发生物标记物，以进行早期检测和风险分层，并允许开发新型的靶向癌症拦截策略。 PCGA背后的多机构，多学科的协作“大数据”工作将有助于开创精密医学用于癌症检测和预防的新时代。 （C）2016 AACR。

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