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首页> 外文期刊>Molecular medicine reports >Melittin, a honeybee venom-derived antimicrobial peptide, may target methicillin-resistant Staphylococcus aureus
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Melittin, a honeybee venom-derived antimicrobial peptide, may target methicillin-resistant Staphylococcus aureus

机译：蜂毒衍生的抗菌肽Melittin可能靶向耐甲氧西林的金黄色葡萄球菌

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摘要

Methicillin-resistant Staphylococcus aureus (MRSA) is difficult to treat using available antibiotic agents. Honeybee venom has been widely used as an oriental treatment for several inflammatory diseases and bacterial infections. The venom contains predominantly biologically active compounds, however, the therapeutic effects of such materials when used to treat MRSA infections have not been investigated extensively. The present study evaluated bee venom and its principal active component, melittin, in terms of their antibacterial activities and in vivo protection against MRSA infections. In vitro, bee venom and melittin exhibited comparable levels of antibacterial activity, which was more marked against MRSA strains, compared with other Gram-positive bacteria. When MRSA-infected mice were treated with bee venom or melittin, only the latter animals were successfully rescued from MRSA- induced bacteraemia or exhibited recovery from MRSA-infected skin wounds. Together, the data of the present study demonstrated for the first time, to the best of our knowledge, that melittin may be used as a promising antimicrobial agent to enhance the healing of MRSA-induced wounds.
机译：耐甲氧西林金黄色葡萄球菌（MRSA）使用现有的抗生素很难治疗。蜜蜂毒已被广泛用作东方治疗几种炎性疾病和细菌感染的方法。毒液主要包含生物活性化合物，但是，这种材料用于治疗MRSA感染的治疗效果尚未得到广泛研究。本研究评估了蜂毒及其主要活性成分蜂毒肽的抗菌活性和体内抗MRSA感染的能力。在体外，与其他革兰氏阳性细菌相比，蜂毒和蜂毒肽具有相当水平的抗菌活性，对MRSA菌株的抵抗力更强。当用蜂毒或蜂毒肽治疗感染了MRSA的小鼠时，只有后者的动物成功地从MRSA诱导的菌血症中解救出来，或从感染MRSA的皮肤伤口中恢复过来。据我们所知，本研究的数据首次证明，蜂毒肽可以用作增强MRSA诱导的伤口愈合的有前途的抗菌剂。

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