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首页> 外文期刊>Molecular medicine reports >Antisense oligonucleotides targeting human telomerase mRNA increases the radiosensitivity of nasopharyngeal carcinoma cells
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Antisense oligonucleotides targeting human telomerase mRNA increases the radiosensitivity of nasopharyngeal carcinoma cells

机译：靶向人类端粒酶mRNA的反义寡核苷酸可提高鼻咽癌细胞的放射敏感性

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摘要

Nasopharyngeal carcinoma (NPC) is associated with a high incidence rate in South China and is predominantly treated with radiotherapy; however, the survival rate remains low. The therapeutic effects of radiation and chemotherapy may be enhanced when combined with anti-sense oligonucleotides targeting human telomerase RNA (hTR ASODN). However, the influence of hTR ASODN on the anti-tumor effects of radiation in NPC remain unknown. The present study investigated the effects of hTR ASODN on the proliferation and radiosensitivity of NPC cells, and further explored the underlying mechanisms. hTR ASODN significantly inhibited the proliferation and decreased the telomere length of CNE-2 human NPC cells. Furthermore, combined treatment of hTR ASODN with radiation significantly enhanced anti-tumor efficacy. The apoptotic rate and cleavage of caspase 9 were increased in the cells treated with the combined therapy, as compared with the cells treated with hTR ASODN or radiotherapy alone. In conclusion, these results suggest that hTR ASODN may inhibit the proliferation of NPC cells and enhance the anti-tumor effects of radiation by inducing cell apoptosis. Therefore hTR ASODN may be a potential adjuvant agent for the treatment of NPC combined with radiation therapy, and these findings are of translational importance.
机译：鼻咽癌（NPC）在华南地区发病率高，主要以放疗治疗。但是，存活率仍然很低。当与靶向人端粒酶RNA（hTR ASODN）的反义寡核苷酸组合使用时，放疗和化疗的治疗效果可能会增强。但是，hTR ASODN对NPC辐射的抗肿瘤作用的影响仍然未知。本研究调查了hTR ASODN对NPC细胞增殖和放射敏感性的影响，并进一步探讨了其潜在机制。 hTR ASODN显着抑制CNE-2人NPC细胞的增殖并降低其端粒长度。此外，hTR ASODN与放射线的联合治疗显着增强了抗肿瘤功效。与单独用hTR ASODN或单独放射治疗的细胞相比，在联合治疗的细胞中caspase 9的凋亡率和裂解增加。总之，这些结果表明，hTR ASODN可能通过诱导细胞凋亡来抑制NPC细胞的增殖并增强放射线的抗肿瘤作用。因此，hTR ASODN可能是结合放射疗法治疗NPC的潜在佐剂，这些发现具有重要的翻译意义。

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