首页> 外文期刊>Molecular medicine today >Recent advances in the genetics of allergy and asthma.
【24h】

Recent advances in the genetics of allergy and asthma.

机译:过敏和哮喘遗传学的最新进展。

获取原文
获取原文并翻译 | 示例
           

摘要

Asthma is a common condition that results from the interaction of an unknown number of genes with environmental factors. About 10% of children have asthma, usually as part of a syndrome of atopy, which is characterized by the presence of allergy, asthma, seasonal rhinitis and eczema, and tends to occur in familial clusters. The incidence of asthma is lower in adults (5%) and a significant proportion is seen without an atopic background. The prevalence of asthma has increased substantially over the past decades, particularly in the western world. Allergy and asthma are not inherited as single-gene disorders and do not show a simple pattern of inheritance. Environmental and genetic factors interact in a complex fashion to produce disease susceptibility and expression. Here, we describe the recent advances in the understanding of the inherited susceptibility to asthma and atopy and discuss their potential implications.
机译:哮喘是一种常见病,是由于未知数量的基因与环境因素相互作用而导致的。约有10%的儿童患有哮喘,通常是特应性综合症的一部分,其特征是存在过敏,哮喘,季节性鼻炎和湿疹,并且往往发生在家族性人群中。成人哮喘的发生率较低(5%),并且在无特应性背景的情况下可观察到很大比例的哮喘。在过去的几十年中,哮喘的患病率大大增加,尤其是在西方世界。过敏和哮喘不会作为单基因疾病遗传,也不会显示出简单的遗传模式。环境和遗传因素以复杂的方式相互作用以产生疾病的易感性和表达。在这里,我们描述了对哮喘和特应性遗传易感性的理解的最新进展,并讨论了它们的潜在含义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号