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首页> 外文期刊>Molecular medicine reports >Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate-induced breast carcinoma cell invasion
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Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate-induced breast carcinoma cell invasion

机译：二苯甲酰甲烷，羟二苯甲酰甲烷和羟甲基二苯甲酰甲烷抑制phorbol-12-肉豆蔻酸酯13-乙酸酯诱导的乳腺癌细胞侵袭

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Dibenzoylmethane (DB), a minor constituent of the root extract of licorice, belongs to the flavonoid family. Hydroxydibenzoylmethane (HDB) and hydroxymethyldibenzoylmethane (HMDB) have an identical structure to DB, but also possess a hydroxyl group and a hydroxyl and methyl group bonded to aromatic rings, respectively. They inhibit cellular proliferation and induce apoptosis in a variety of types of cancer cell, however, the antimetastatic effects of DB, HDB and HMDB on human breast carcinoma cells remain to be elucidated. The present study aimed to clarify the molecular mechanisms underlying the effects of DB and its analogues on phorbol-12-myristate 13-acetate (PMA)-induced MCF-7 cell metastasis. The results revealed that DB, HDB and HMDB inhibited cell migration and invasion. In addition, PMA-mediated MCF-7 cell invasion was inhibited by DB, HDB and HMDB by inhibiting the expression of matrix metalloproteinase (MMP)-9. Rottlerin, a protein kinase C (PKC) delta inhibitor and LY294002, a phosphatidylinositide 3-kinase (PI3K) inhibitor, reduced the PMA-mediated expression of MMP-9 and cell invasion. Furthermore, DB, HDB and HMDB prevented the activation of PKC delta and PI3K by inhibiting their phosphorylation. The present study was the first, to the best of our knowledge, to demonstrate the antimetastatic potential of DB, HDB and HDMB, which decreased cancer cell invasion through the PI3K/PKC delta-mediated MMP-9 pathway.
机译：二苯甲酰甲烷（DB）是甘草根提取物中的次要成分，属于类黄酮家族。羟基二苯甲酰基甲烷（HDB）和羟甲基二苯甲酰基甲烷（HMDB）具有与DB相同的结构，但分别具有与芳环键合的羟基和羟基和甲基。它们抑制细胞增殖并在多种类型的癌细胞中诱导凋亡，但是，DB，HDB和HMDB对人乳腺癌细胞的抗转移作用仍有待阐明。本研究旨在阐明DB及其类似物对佛波-12-肉豆蔻酸酯13-乙酸酯（PMA）诱导的MCF-7细胞转移的影响的分子机制。结果表明，DB，HDB和HMDB抑制细胞迁移和侵袭。此外，DB，HDB和HMDB通过抑制基质金属蛋白酶（MMP）-9的表达来抑制PMA介导的MCF-7细胞侵袭。蛋白质激酶C（PKC）δ抑制剂Rottlerin和磷脂酰肌醇3激酶（PI3K）抑制剂LY294002降低了PMA介导的MMP-9表达和细胞侵袭。此外，DB，HDB和HMDB通过抑制它们的磷酸化来阻止PKCδ和PI3K的活化。据我们所知，本研究是第一个证明DB，HDB和HDMB具有抗转移潜力的物质，它通过PI3K / PKCδ介导的MMP-9途径减少了癌细胞的侵袭。

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