...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular pharmaceutics >Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery
【24h】

Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery

机译：由光响应性材料制成的水凝胶型微针阵列，用于按需透皮给药

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We describe, for the first time, stimulus responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micro molding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 h). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in "on-demand" delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.
机译：我们首次描述了刺激响应的水凝胶形成微针（MN）阵列，该阵列能够在应用光后交付临床相关模型药物（ibuprofen）。使用由甲基丙烯酸2-羟乙酯（HEMA）和乙二醇二甲基丙烯酸酯（EGDMA）制备的聚合物通过微模制制备MN阵列。所获得的MN阵列显示出良好的机械性能。该系统装有光反应性3,5-二甲氧基安息香共轭物中所含的高达5％（w / w）布洛芬。拉曼光谱法证实了聚合物MN基质内部存在缀合物。在体外，该系统能够在延长的时间段（长达160小时）内应用光触发，最多递送三剂50 mg布洛芬。这使得该系统可以长时间用作控制释放装置。我们相信，这项技术有潜力用于“按需”递送各种药物，与改善患者护理相关的各种应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号