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首页> 外文期刊>Molecular pharmacology. >Intermolecular interactions of Sprouty proteins and their implications in development and disease.
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Intermolecular interactions of Sprouty proteins and their implications in development and disease.

机译：Sprouty蛋白的分子间相互作用及其对发育和疾病的影响。

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摘要

Receptor tyrosine kinase (RTK) signaling is spatially and temporally regulated by a number of positive and negative regulatory mechanisms. These regulatory mechanisms control the amplitude and duration of the signals initiated at the cell surface to have a normal or aberrant biological outcome in development and disease, respectively. In the past decade, the Sprouty (Spry) family of proteins has been identified as modulators of RTK signaling in normal development and disease. This review summarizes recent advances concerning the biological activities modulated by Spry family proteins, their interactions with signaling proteins, and their involvement in cardiovascular diseases and cancer. The diversity of mechanisms in the regulation of Spry expression and activity in cell systems emphasizes the crucial role of Spry proteins in development and growth across the animal kingdom.
机译：受体酪氨酸激酶（RTK）信号在空间和时间上受到许多积极和消极调节机制的调节。这些调节机制控制在细胞表面引发的信号的幅度和持续时间，使其分别在发育和疾病中具有正常或异常的生物学结果。在过去的十年中，Sprouty（Spry）蛋白家族已被确定为正常发育和疾病中RTK信号传导的调节剂。这篇综述总结了有关Spry家族蛋白调节的生物活性，它们与信号蛋白的相互作用以及它们参与心血管疾病和癌症的最新进展。在细胞系统中调节Spry表达和活性的机制的多样性强调了Spry蛋白在整个动物界的发育和生长中的关键作用。

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