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首页> 外文期刊>Molecular urology >Prognostic significance of immuno-proteosome subunit expression in patients with renal-cell carcinoma: A preliminary study
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Prognostic significance of immuno-proteosome subunit expression in patients with renal-cell carcinoma: A preliminary study

机译：免疫蛋白亚基表达在肾细胞癌患者中的预后意义：初步研究

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摘要

Our purpose was to elucidate the clinical roles of the "immuno-proteosome," which is involved in the accelerated pathway of the major histocompatibility complex (MHC) class I-restricted antigen presentation system, in renal cell carcinoma (RCC). The relative expression of six proteosome subunits (existing subunits X, Y, and Z and immunoproteosome subunits LMP7, LMP2, and MECL1) in 54 RCCs was investigated using RT-PCR analysis and was compared with clinicopathological measures, including patient outcome. Expression of the LMP7 and LMP2 genes was significantly low in high-grade tumors, and that of the LMP7 and MECL1 genes was significantly low in high-stage tumors. Low levels of LMP7, LMP2, and MECL1 expression were strongly associated with shortened survival (LMP7: P = 0.0002, LMP2: P < 0.0001, MECL1: P < 0.0047). The levels of subunits X, Y, and Z had no significant correlation with those measures. These findings suggest that RCCs with low level of immuno-proteosome subunit expression have a disorder in their antigen-presentation system. As a consequence, they may escape from immune surveillance and worsen patient outcome.
机译：我们的目的是阐明“免疫蛋白体”在肾细胞癌（RCC）中的临床作用，该蛋白体参与了主要组织相容性复合体（MHC）I类限制性抗原呈递系统的加速途径。使用RT-PCR分析了54个RCC中6个蛋白体亚基（现有的X，Y和Z以及免疫蛋白体亚基LMP7，LMP2和MECL1）的相对表达，并与临床病理指标（包括患者预后）进行了比较。 LMP7和LMP2基因在高级别肿瘤中的表达明显较低，而LMP7和MECL1基因在高级别肿瘤中的表达则较低。 LMP7，LMP2和MECL1表达水平低与生存期缩短密切相关（LMP7：P = 0.0002，LMP2：P <0.0001，MECL1：P <0.0047）。 X，Y和Z亚基的水平与这些指标没有显着相关性。这些发现表明，免疫蛋白亚基表达水平较低的RCC在其抗原呈递系统中存在障碍。结果，它们可能会脱离免疫监测并恶化患者预后。

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