Application of Cre-loxP system to the urinary tract and cancer gene therapy.

Yoshimura I; Suzuki S; Hayakawa M

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Application of Cre-loxP system to the urinary tract and cancer gene therapy.

机译：Cre-loxP系统在泌尿道和癌症基因治疗中的应用。

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摘要

The bacteriophage P1-derived Cre-loxP system is a powerful and versatile tool for in vivo DNA recombination. It is widely used in gene targeting research. The combination of the Cre-loxP system and a specific promoter enables conditional "knockout" of a target gene in a particular tissue or cell type. It has also made it possible to delete genes in adult animals that are essential for embryogenesis. This system is also used to enhance tissue- or tumor-specific promoter activities that are useful for gene therapy of certain types of cancer. It is expected that this simple and effective system will be further utilized in various research applications.

机译：源自噬菌体P1的Cre-loxP系统是用于体内DNA重组的强大而多功能的工具。它广泛用于基因靶向研究。 Cre-loxP系统和特定启动子的组合使特定组织或细胞类型中靶基因的条件“敲除”成为可能。这也使得删除成年动物胚胎发生必不可少的基因成为可能。该系统还用于增强组织或肿瘤特异性启动子活性，可用于某些类型的癌症的基因治疗。期望该简单有效的系统将在各种研究应用中得到进一步利用。

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《Molecular urology》 |2001年第2期|共4页
作者
Yoshimura I; Suzuki S; Hayakawa M;
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正文语种 eng
中图分类妇产科学;
关键词
Gene Targeting; Gene Therapy; Integrases; Urinary Tract Physiology; Urologic Neoplasms; 基因靶效应; 基因疗法; 泌尿道生理学; 泌尿系肿瘤; 病毒蛋白质类;

机译：Gene Targeting;Gene Therapy;Integrases;Urinary Tract Physiology;Urologic Neoplasms;基因靶效应;基因疗法;泌尿道生理学;泌尿系肿瘤;病毒蛋白质类;

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专利

1. Application of Cre-loxP system to the urinary tract and cancer gene therapy. [J] . Yoshimura I, Suzuki S, Hayakawa M Molecular urology . 2001,第2期

机译：Cre-loxP系统在泌尿道和癌症基因治疗中的应用。
2. Occupational exposures and genetic susceptibility to urinary tract cancers: a systematic review and meta-analysis [J] . Stojanovic Jovana, Milovanovic Sonja, Pastorino Roberta, European journal of cancer prevention: The official journal of the European Cancer Prevention Organisation (ECP) . 2018,第5期

机译：患有泌尿道癌症的职业暴露和遗传易感性：系统审查和荟萃分析
3. Application of the Cre-loxP system for multiple gene disruption in the yeast Kluyveromyces marxianus [J] . Ribeiro O, Gombert AK, Teixeira JA, Journal of Biotechnology . 2007,第1期

机译：Cre-loxP系统在马尔克斯克鲁维酵母中多基因破坏中的应用
4. PROSPECTIVE TRIAL OF 5-AZACITIDINE IN DOGS WITH NATURALLY-OCCURRING INVASIVE URINARY BLADDER CANCER, AN EPIGENETIC APPROACH TO CANCER THERAPY. [C] . Noah Hahn, Deborah Knapp, Michael Childress, Annual Conference of the Veterinary Cancer Society . 2009

机译：患有自然侵袭性膀胱癌的5-氮杂氨酸的前瞻性试验，癌症治疗的表观遗传方法。
5. Development of improved expression vectors and their applications in cancer gene therapy. [D] . Luo, Phoebe Lihong. 2003

机译：改良表达载体的开发及其在癌症基因治疗中的应用。
6. Retroviral vectors containing putative internal ribosome entry sites: development of a polycistronic gene transfer system and applications to human gene therapy. [O] . R A Morgan, L Couture, O Elroy-Stein, 1992

机译：包含推定的内部核糖体进入位点的逆转录病毒载体：多顺反子基因转移系统的开发及其在人类基因治疗中的应用。
7. High expression of gastrin-releasing peptide receptors in the vascular bed of urinary tract cancers: promising candidates for vascular targeting applications [O] . Fleischmann, Achim, Waser, Beatrice, Reubi, Jean Claude 2009

机译：胃泌素释放肽受体在尿道癌血管床中的高表达：血管靶向应用的有希望的候选者
8. Algorithms for the Determination of Spatial and Spectral Distribution of Electromagnetic Energy in a Simulated Biostructure Subjected to Transient Spatially Heterogeneous Radiation with Applications to Radar Hazard Assessment and Cancer Therapy. [R] . Cohoon, D. K. 1992

机译：瞬态空间非均匀辐射下模拟生物结构中电磁能量空间和光谱分布的确定算法及其在雷达危害评估和癌症治疗中的应用。

Application of Cre-loxP system to the urinary tract and cancer gene therapy.

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