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首页> 外文期刊>Multiple sclerosis: clinical and laboratory research >Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 Vitamin D receptor variant in this interaction.
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Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 Vitamin D receptor variant in this interaction.

机译：过去的环境阳光照射和多发性硬化症的风险：Cdx-2维生素D受体变异体在这种相互作用中的作用。

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Multiple studies have provided evidence for an association between reduced sun exposure and increased risk of multiple sclerosis (MS), an association likely to be mediated, at least in part, by the vitamin D hormonal pathway. Herein, we examine whether the vitamin D receptor (VDR), an integral component of this pathway, influences MS risk in a population-based sample where winter sun exposure in early childhood has been found to be an important determinant of MS risk. Three polymorphisms within the VDR gene were genotyped in 136 MS cases and 235 controls, and associations with MS and past sun exposure were examined by logistic regression. No significant univariate associations between the polymorphisms, rs11574010 (Cdx-2A > G), rs10735810 (Fok1T > C), or rs731236 (Taq1C > T) and MS risk were observed. However, a significant interaction was observed between winter sun exposure during childhood, genotype at rs11574010, and MS risk (P = 0.012), with the 'G' allele conferring an increased risk of MS in the low sun exposure group (
机译：多项研究为减少阳光照射和增加多发性硬化症（MS）的风险之间的关联提供了证据，该关联可能至少部分地由维生素D激素途径介导。本文中，我们研究了维生素D受体（VDR）是否是该途径不可或缺的组成部分，在以人口为基础的样本中是否影响了MS风险，在该样本中已发现儿童早期的冬季太阳暴晒是MS风险的重要决定因素。在136名MS患者和235名对照中对VDR基因内的3个多态性进行了基因分型，并通过logistic回归分析了与MS和过往日照的关联。没有观察到多态性，rs11574010（Cdx-2A> G），rs10735810（Fok1T> C）或rs731236（Taq1C> T）和MS风险之间存在显着的单变量关联。然而，在儿童期的冬季太阳照射，rs11574010的基因型和MS风险之间观察到显着的相互作用（P = 0.012），“ G”等位基因在低阳光照射组中增加了MS的风险（

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