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18F)-Dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism.

机译:18F)-多巴正电子发射断层显像在早期非帕金森病青少年帕金森病中的应用。

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摘要

There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of (18)F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene.
机译:关于青少年帕金森病(JP)的正电子发射断层扫描(PET)报道很少。我们报告(18)F-6-氟-L-多巴(FD)PET在一名14岁,病程为5年,伴有非典型特征的JP患者中的结果。这是迄今为止最年轻的主题。纹状体FD摄取严重不对称减少,壳状核的尾状尾骨梯度与成人发作的特发性帕金森病相似。该患者的大量DNA分析未显示出parkin基因突变。

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