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首页> 外文期刊>Mutation Research, A. Reviews in Genetic Toxicology >Quantification of low-level radiation exposure by conventional chromosome aberration analysis
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Quantification of low-level radiation exposure by conventional chromosome aberration analysis

机译：通过常规染色体像差分析定量低水平辐射

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摘要

Chromosome dosimctry, in its conventional form largely based on scoring of dicentrics and ring chromosomes in human blood lymphocytes, is the most widely distributed and reliable biological technique in radiological protection to estimate individual whole-body doses of about 100 mGy of low-LET radiation. Attempts to detect and quantify effects even of lower acute doses or protracted and chronic exposures have been repeatedly performed and the results revealed inherent limitations of this approach. Most relevant items, such as extrapolating from high-dose to low-dose effects, the influence of background frequency of dicentrics on the dose estimates, dose accumulation and concomitant temporal decline of the yields of unstable dicentrics or the statistical analyses of the data and their implications for quantifying low-level radiation exposure will be discussed in this report.
机译：染色体放射学，其传统形式主要基于人类血液淋巴细胞中双着丝粒和环状染色体的得分，是放射防护中分布最广泛，最可靠的生物学技术，用于估计大约100 mGy的低LET辐射的个体全身剂量。尝试反复检测和量化甚至较低急性剂量或长期和长期接触的影响，结果揭示了这种方法的固有局限性。最相关的项目，例如从高剂量效应到低剂量效应的推断，双着丝粒的背景频率对剂量估计的影响，剂量积累和不稳定双着丝粒的产量随时间的下降或数据及其统计分析本报告将讨论量化低辐射暴露的意义。

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