In vivo genotoxic interactions among three phenolic benzene metabolites

A. Marrazzini; L. Chelotti; I. Barrai; N. Loprieno; R. Barale

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In vivo genotoxic interactions among three phenolic benzene metabolites

机译：三种酚类苯代谢物之间的体内遗传毒性相互作用

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Three benzene metabolites, hydroquinone (HQ), cathecol (CAT) and phenol (PHE) were studied to define their possible interaction in inducing micronuclei (Mn) in mouse bone marrow polychromatic erythrocyles (PCEs). HO and CAT, administered separately, induced Mn while PHE showed no genotoxic effects. Binary and ternary mixtures of two or three metabolites gave different results, causing considerable increase or decrease: in Mn induction. HQ and PHE, in binary mixtures, as well as PHE and CAT, increasedMn synergistically, while HQ and CAT interacted negatively. The genbtoxicity of ternary mixtures was mainly the consequence of two metabolites: HQ and CAT. The maximal effect obtained is far below the induction of Mn consequent to benzene trcament. These data suggest that toxic and genotoxic effects of benzene alone could be the result of more complex interactions among these and other metabolites.

机译：研究了三种苯代谢物，对苯二酚（HQ），乙醇（CAT）和苯酚（PHE），以定义它们在诱导小鼠骨髓多色红藻类（PCE）中的微核（Mn）中可能的相互作用。 HO和CAT分开施用可诱导Mn，而PHE则无遗传毒性。两种或三种代谢物的二元和三元混合物产生不同的结果，从而导致相当大的增加或减少：锰的诱导。在二元混合物中，HQ和PHE以及PHE和CAT协同增加Mn，而HQ和CAT则负向相互作用。三元混合物的产生毒性主要是由于两种代谢产物：HQ和CAT的结果。所获得的最大效果远低于苯ca对锰的诱导。这些数据表明，仅苯的毒性和遗传毒性作用可能是这些代谢物与其他代谢物之间更复杂的相互作用的结果。

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《Mutation Research, A. Reviews in Genetic Toxicology》 |1995年第1期|共18页
作者
A. Marrazzini; L. Chelotti; I. Barrai; N. Loprieno; R. Barale;
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正文语种 eng
中图分类遗传学;
关键词
Benzene; Hydroquinone; Cathecol; Phenol; Interaction; Mouse; Micronuclei;

机译：苯;氢醌;乙醇;苯酚;相互作用;小鼠;微核;

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1. In vivo genotoxic interactions among three phenolic benzene metabolites [J] . A. Marrazzini, L. Chelotti, I. Barrai, Mutation Research, A. Reviews in Genetic Toxicology . 1995,第1期

机译：三种酚类苯代谢物之间的体内遗传毒性相互作用
2. Human urine certified reference material CZ 6010: creatinine and toluene metabolites (hippuric acid and o-cresol) and a benzene metabolite (phenol) [J] . I. Šperlingová, L. Dabrowská, V. Stránský, Analytical and Bioanalytical Chemistry . 2007,第7期

机译：经人类尿液认证的参考材料CZ 6010：肌酸酐和甲苯代谢物（庚二酸和邻甲酚）和苯代谢物（苯酚）
3. Preliminary study to prepare a reference material of toluene metabolite - o-cresol and benzene metabolite-phenol - in human urine [J] . Sperlingova I, Dabrowska L, Stransky V, Accreditation and quality assurance . 2006,第5期

机译：制备尿液中甲苯代谢物-邻甲酚和苯代谢物-苯酚的参考物质的初步研究
4. EFFECTS OF CO-EXPOSURE TO 50 HZ MAGNETIC FIELD AND BENZENE OR BENZENE METABOLITES DETERMINED IN VITRO BY THE ALKALINE COMET ASSAY [C] . International non-ionizing radiation workshop symposium . 2004

机译：通过碱性彗星测定对50Hz磁场和苯或苯或苯代谢物测定的影响
5. Benzene-metabolite-induced apoptosis: Implications of the NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism for susceptibility of hematopoietic cells to phenolic metabolites [D] . Moran, Julie L. 1999

机译：苯代谢物诱导的细胞凋亡：NAD（P）H：醌氧化还原酶1（NQO1）C609T多态性对造血细胞对酚类代谢物的敏感性的影响
6. Peroxidase-dependent metabolism of benzenes phenolic metabolites and its potential role in benzene toxicity and carcinogenicity. [O] . M T Smith, J W Yager, K L Steinmetz, 1989

机译：苯酚代谢产物的过氧化物酶依赖性代谢及其在苯毒性和致癌性中的潜在作用。
7. Comparison of the repair of DNA damage induced by the benzene metabolites hydroquinone and p-benzoquinone: a role for hydroquinone in benzene genotoxicity [O] . M. Gaskell 2004

机译：苯代谢物氢醌和对苯醌诱导的DNA损伤修复的比较：苯脱毒毒性氢醌的作用

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In vivo genotoxic interactions among three phenolic benzene metabolites

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