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首页> 外文期刊>Mutation Research, A. Reviews in Genetic Toxicology >Important biological variables that can influence the degree of chemical-induced aneuploidy in mammalian oocyte and zygotes
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Important biological variables that can influence the degree of chemical-induced aneuploidy in mammalian oocyte and zygotes

机译：可能影响哺乳动物卵母细胞和受精卵化学诱导的非整倍性程度的重要生物学变量

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The ability of certain chemicals to increase the frequency of aneuploidy in mammalian oocytes elicits concern about human health and well-being. This concernment exists because aneuploidy is the most prevalent class of human genetic disorders, and very little information exists about the etiology of aneuploidy. Although there are experimental models for studying aneuploidy in female germ cells and zygotes, these models arc still being validated because insufficient information exists about the biological variables that can influence the degree of chemical-induced aneuploidy. In this regard, variables such as dose, solvent, use of gonadotrophins, mode and preovulatory time of chemical administration, time of cell harvest relative to the possibility of chemical-induced rneiotlc delay, criteria for cytogenetic analysis and data reporting, and an introduction to differences between cell types and sexes are presented. Besides these variables, additional information is needed about the various molecularmechanisms associated with oocyte mciotic maturation and the genesis of aneuploidy. Also, differences between the results from selected chromosome analysis and DNA-liybridization studies ore presented. Based .upon the various biologic endpoims measured and the differences in cellular physiology and biochemical pathways, agreement among the results from different aneuploidy assays cannot necessarily be expected. To gain further insight into the etiology of aneuploidy in female germ cells, information isneeded about the chemical interactions between endogenous and exogenous compounds and those involved with odcyte melotic maturation.
机译：某些化学物质增加哺乳动物卵母细胞非整倍性频率的能力引起人们对人类健康和福祉的关注。存在这种担忧是因为非整倍性是人类遗传疾病中最普遍的一类，而关于非整倍性病因的信息很少。尽管存在用于研究雌性生殖细胞和受精卵中非整倍性的实验模型，但是这些模型仍在验证中，因为关于可影响化学诱导的非整倍性程度的生物学变量的信息不足。在这方面，变量包括剂量，溶剂，促性腺激素的使用，化学给药的方式和排卵前的时间，相对于化学诱导的神经细胞延迟的可能性的细胞收获时间，细胞遗传学分析和数据报告的标准以及介绍了细胞类型和性别之间的差异。除了这些变量，还需要有关与卵母细胞成熟和非整倍性发生有关的各种分子机制的其他信息。此外，还显示了所选染色体分析结果与DNA杂交研究结果之间的差异。基于所测量的各种生物内在因子以及细胞生理学和生化途径的差异，不一定可以预期不同非整倍性测定法的结果之间的一致性。为了进一步了解雌性生殖细胞中非整倍性的病因，需要有关内源性和外源性化合物与odcyte melotic成熟相关化合物之间化学相互作用的信息。

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