• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Mutation Research, A. Reviews in Genetic Toxicology >Chemical structure and genotoxicity: studies of the SOS chromotest
【24h】

Chemical structure and genotoxicity: studies of the SOS chromotest

机译：化学结构和遗传毒性：SOS色度试验的研究

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Analyses of a data base consisting of 461 chemicals tested in the SOS chromotest with MULTICASE resulted in the development of an SAR mo'del that displayed a highly significant concordance (87.3%) between experimental and predicted results of chemicals not included in the model. An analysis of the nature of the biophores and their modulators revealed that electropthilicity and structural features affecting: (a) accessibility of the electrophile to the nucleophilic site on the DNA; and (b) the bulkiness of the DNA addnct were factors determining the probability that a chemical would induce DNA error prone repair and if so the extent of this activity. Additional analyses indicated that there were significant mechanistic similarities between the SOS chromotest and mutations in Salmonella as determined in the standard ('Ames') assay,
机译：在MULTICASE的SOS色度测试中对由461种化学物质组成的数据库进行的分析导致开发出SAR模式，该模式在模型中未包含的化学实验结果与预测结果之间显示出非常显着的一致性（87.3％）。对生物体及其调节剂的性质的分析表明，电可塑性和结构特征影响：（a）亲电体对DNA上亲核位点的可及性; （b）DNA的庞大性是决定化学物质诱导DNA易错修复的可能性以及这种活性程度的因素。其他分析表明，通过标准（'Ames'）分析确定，SOS色度测试与沙门氏菌突变之间存在明显的机械相似性，

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号