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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >COMPARISON OF GAMMA-RAY INDUCED DICENTRIC YIELDS IN HUMAN LYMPHOCYTES MEASURED BY CONVENTIONAL ANALYSIS AND FISH
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COMPARISON OF GAMMA-RAY INDUCED DICENTRIC YIELDS IN HUMAN LYMPHOCYTES MEASURED BY CONVENTIONAL ANALYSIS AND FISH

机译：常规分析法和鱼法测定γ射线诱导人淋巴细胞中偏心率的比较

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摘要

In an earlier work stable aberrations and dicentrics were determined by fluorescence in situ hybridization (FISH) after various doses of Cs-137 gamma-rays. No corresponding calibration curve for dicentrics is available for determinations in terms of the conventional analysis as performed in our laboratory. In view of the potential for the application of chromosome painting to human biological dosimetry, it is desirable to determine such a calibration curve and this and the comparison of the resulting data to those obtained in terms of the FISH method is the objective of the present communication. In the study it is found that the linear-quadratic dose response curves for dicentrics, that are determined by the two methods, are significantly different, although the different target sizes are accounted for. A similar problem was found earlier for X-rays. It does not appear that the difference is due to technical difficulties in the FISH method, that has been improved by employing in addition to the whole chromosome DNA probes, a pan-centromeric DNA probe.
机译：在较早的工作中，在各种剂量的Cs-137伽玛射线照射后，通过荧光原位杂交（FISH）确定了稳定的像差和双着丝粒。根据我们实验室进行的常规分析，没有相应的双心校准曲线可用于测定。考虑到将染色体涂装应用于人类生物剂量学的潜力，希望确定这样的校准曲线，并将其与通过FISH方法获得的结果进行比较是本通讯的目的。 。在研究中发现，尽管考虑了不同的目标尺寸，但通过两种方法确定的双着丝粒的线性二次剂量响应曲线存在显着差异。 X射线先前也发现了类似的问题。差异似乎不是由于FISH方法的技术难题引起的，这种方法已通过除了使用整个染色体DNA探针之外还使用了全着丝粒DNA探针得到了改善。

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