INTERFERON-ALPHA OR BETA POTENTIATE PLATINUM ANALOGOUS IN HUMAN GLIOBLASTOMA CELL LINES

Stanzione S; Cimoli G; Debernardis D; Michelotti A; Conte PF; Parodi

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INTERFERON-ALPHA OR BETA POTENTIATE PLATINUM ANALOGOUS IN HUMAN GLIOBLASTOMA CELL LINES

机译：人胶质母细胞瘤细胞系中的干扰素-α或β-贝塔蛋白类似物

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The effect of interferon-alpha or beta on platinum analogues [cisplatin (CDDP) and carboplatin] cytotoxicity was studied in four glioblastoma cell lines (U373MG, T98G, A172 and U118Mg). All cell lines were strongly resistant to the cytotoxic effect of CDDP or carboplatin. Although both interferons were not cytotoxic in all cell lines, they were able to significantly increase the cell platinum-sensitivity. Specifically interferon-a increased the magnitude of CDDP-induced DNA interstrand crosslinks.

机译：在四种胶质母细胞瘤细胞系（U373MG，T98G，A172和U118Mg）中研究了干扰素-α或β对铂类似物[顺铂（CDDP）和卡铂]的细胞毒性作用。所有细胞系均对CDDP或卡铂的细胞毒性作用具有强烈的抵抗力。尽管两种干扰素在所有细胞系中都不具有细胞毒性，但它们能够显着提高细胞对铂的敏感性。具体而言，干扰素-α增加了CDDP诱导的DNA链间交联的幅度。

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《Mutation Research, C. Mutation Research Letters》 |1995年第3期|共5页
作者
Stanzione S; Cimoli G; Debernardis D; Michelotti A; Conte PF; Parodi;
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正文语种 eng
中图分类遗传学;
关键词
Interferons; Platinum; Dna damage; Potentiation; Glioma; Chemotherapy; Etoposide; Gliomas;

机译：干扰素;铂;Dna损伤;潜伏期;神经胶质瘤;化学疗法;依托泊苷;胶质瘤;

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1. INTERFERON-ALPHA OR BETA POTENTIATE PLATINUM ANALOGOUS IN HUMAN GLIOBLASTOMA CELL LINES [J] . Stanzione S, Cimoli G, Debernardis D, Mutation Research, C. Mutation Research Letters . 1995,第3期

机译：人胶质母细胞瘤细胞系中的干扰素-α或β-贝塔蛋白类似物
2. Lithium chloride and staurosporine potentiate the accumulation of phosphorylated glycogen synthase kinase 3beta/Tyr216, resulting in glycogen synthase kinase 3beta activation in SH-SY5Y human neuroblastoma cell lines. [J] . Noel A, Barrier L, Rinaldi F, Journal of Neuroscience Research . 2011,第5期

机译：氯化锂和星形孢菌素增强磷酸化糖原合酶激酶3beta / Tyr216的积累，导致SH-SY5Y人神经母细胞瘤细胞系中糖原合酶激酶3beta活化。
3. 18beta-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines. [J] . Lee CS, Yang JC, Kim YJ, European Journal of Pharmacology: An International Journal . 2010,第1a3期

机译：18β-甘草次酸增强曲古抑菌素A对人上皮性卵巢癌细胞系的凋亡作用。
4. Proteomics Profiling of Human Glioblastoma U87-MG, LNZ308, SNB19 and LN18 Cell Lines [C] . Vadiraja B. Bhat, Christine Miller, Vaibhav Chumbalkar, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：人胶质细胞瘤U87-Mg，LNZ308，SNB19和LN18细胞系的蛋白质组学分析
5. Type 1 sodium hydrogen exchanger NHE1 in human glioblastoma cell lines: NHE1 inhibition results in selective glioblastoma cell death. [D] . Roscoe, Jane Ann. 2002

机译：人胶质母细胞瘤细胞系中的1型钠氢交换剂NHE1：NHE1抑制导致选择性胶质母细胞瘤细胞死亡。
6. Enhanced expression in vivo of HLA-ABC antigens and beta 2-microglobulin on human lymphoid cells induced by human interferon-alpha in patients with lung cancer. Enhanced expression of class I major histocompatibility antigens prior to treatment. [O] . M H Nissen, T Plesner, J K Larsen, 1985

机译：肺癌患者中人干扰素-α诱导的人淋巴样细胞上HLA-ABC抗原和β2-微球蛋白的体内表达增强。治疗前增强的I类主要组织相容性抗原的表达。
7. Bovine serum amine oxidase and spm potentiate docetaxel and interferon-alpha effects in inducing apoptosis on human cancer cells through the generation of oxidative stress. [O] . MARRA M, LOMBARDI A, E. AGOSTINELLI, 2008

机译：牛血清胺氧化酶和spm可增强多西他赛和干扰素α的作用，通过产生氧化应激诱导人癌细胞凋亡。

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INTERFERON-ALPHA OR BETA POTENTIATE PLATINUM ANALOGOUS IN HUMAN GLIOBLASTOMA CELL LINES

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